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Prévalence des marqueurs biologiques de la maladie cœliaque dans une cohorte d’enfants et d’adolescents diabétiques de type I

Abstract : The aim of this study was to determine the prevalence of celiac disease (CD) markers in a French cohort of 84 children type 1 diabetics. Detection of antitransglutaminase (AtTG), antiendomysium (AEA) and antigliadin (AGA) antibodies was performed. Group 1 included 81 (96.4%) diabetic patients with negative antibodies. Group 2 included 3 patients (3.6%) with positive serological markers: 1 AGA-AEA-AtTG and 1 AEA-AtTG with proved histological diagnosis and 1 AGA positive with negative histology. No statistically significant difference was observed between the groups with regard to age, duration of diabetes, familial target stature, and ratios Height/Age and Weight/Height. Presence of CD serological markers was related to a lower level of HbA1c. Prevalence of CD serological markers is important in this French cohort but lower than other countries.
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https://hal-univ-tours.archives-ouvertes.fr/hal-02425325
Contributor : Valérie Gouilleux <>
Submitted on : Monday, December 30, 2019 - 12:13:52 PM
Last modification on : Friday, September 18, 2020 - 2:34:34 PM

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S. Beltran, H. Bony-Trifunovic, V. Gouilleux-Gruart, D. Djeddi, I. Dadamessi, et al.. Prévalence des marqueurs biologiques de la maladie cœliaque dans une cohorte d’enfants et d’adolescents diabétiques de type I. Annales d'Endocrinologie, Elsevier Masson, 2004, 65 (2), pp.131-135. ⟨10.1016/s0003-4266(04)95661-2⟩. ⟨hal-02425325⟩

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