[Prevalence of celiac disease markers in a French cohort of children and adolescents with type 1 diabete mellitus].

Prévalence des marqueurs biologiques de la maladie cœliaque dans une cohorte d’enfants et d’adolescents diabétiques de type I

S. Beltran (1) , H. Bony-Trifunovic , V. Gouilleux-Gruart , D. Djeddi , I. Dadamessi , J.L Dupas , Bernard Boudailliez

1 BETM - Biologie et écologie tropicale et méditerranéenne [2007-2010]

The aim of this study was to determine the prevalence of celiac disease (CD) markers in a French cohort of 84 children type 1 diabetics. Detection of antitransglutaminase (AtTG), antiendomysium (AEA) and antigliadin (AGA) antibodies was performed. Group 1 included 81 (96.4%) diabetic patients with negative antibodies. Group 2 included 3 patients (3.6%) with positive serological markers: 1 AGA-AEA-AtTG and 1 AEA-AtTG with proved histological diagnosis and 1 AGA positive with negative histology. No statistically significant difference was observed between the groups with regard to age, duration of diabetes, familial target stature, and ratios Height/Age and Weight/Height. Presence of CD serological markers was related to a lower level of HbA1c. Prevalence of CD serological markers is important in this French cohort but lower than other countries.

Domaines: Sciences du Vivant [q-bio]

S. Beltran, H. Bony-Trifunovic, V. Gouilleux-Gruart, D. Djeddi, I. Dadamessi, et al.. Prévalence des marqueurs biologiques de la maladie cœliaque dans une cohorte d’enfants et d’adolescents diabétiques de type I. Annales d'Endocrinologie, 2004, 65 (2), pp.131-135. ⟨10.1016/s0003-4266(04)95661-2⟩. ⟨hal-02425325⟩