Virus-Associated Nephropathies: A Narrative Review

Christophe Masset (1, 2, 3, 4) , Paul Le Turnier (5) , Céline Bressollette-Bodin (3, 6) , Karine Renaudin (7, 8) , François Raffi (6, 9) , Jacques Dantal (1, 2, 8, 4)

1 Service de Néphrologie et Immunologie Clinique [CHU de Nantes]
2 ITERT - Institut de Transplantation et de Recherche en Transplantation [CHU Nantes]
3 Team 1 - U1064 Inserm - CR2TI - Team 1 : Mononuclear phagocytes, Immunopathology, Immunovirology
4 ITUN - Institut de transplantation urologie-néphrologie
5 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
6 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
7 Service d’Anatomie et Cytologie Pathologiques [CHU Nantes]
8 Team 4 - U1064 Inserm - CR2TI - Team 4 : Deciphering organ immune regulation in inflammation and transplantation (DORI-t)
9 CIC Nantes - Centre d’Investigation Clinique de Nantes

While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity or direct or indirect viral-associated nephropathy. We review here the described virus-associated nephropathies in order to guide diagnosis strategies and treatments in cases of acute kidney injury (AKI) occurring concomitantly with a viral infection. The occurrence of virusassociated nephropathy depends on multiple factors: the local epidemiology of the virus, its ability to infect renal cells and the patient's underlying immune response, which varies with the state of immunosuppression. Clear comprehension of pathophysiological mechanisms associated with a summary of described direct and indirect injuries should help physicians to diagnose and treat viral associated nephropathies.

Mots clés: viral infection; nephropathy; acute kidney injury; glomerulopathy

Domaines: Sciences du Vivant [q-bio]

Christophe Masset, Paul Le Turnier, Céline Bressollette-Bodin, Karine Renaudin, François Raffi, et al.. Virus-Associated Nephropathies: A Narrative Review. International Journal of Molecular Sciences, 2022, 23 (19), pp.12014. ⟨10.3390/ijms231912014⟩. ⟨inserm-03881255⟩