Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens, Vaccine, vol.33, pp.4843-4852, 2015. ,
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response, Immunity, vol.38, pp.106-124, 2013. ,
,
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus, Cell, vol.139, pp.1243-54, 2009. ,
Vande Woude, the respiratory and intestinal mucosal surfaces and is produced after systemic administration of flagellin in mice, 2010. ,
In our study, although we confirmed the IL-22 production after flagellin administration, IL-22-deficient mice still managed to reduce M1 RNA upon flagellin treatment, 2012. ,
Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens, Vaccine, vol.33, pp.4843-4852, 2015. ,
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response, Immunity, vol.38, pp.106-124, 2013. ,
,
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus, Cell, vol.139, pp.1243-54, 2009. ,
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection, J Exp Med, vol.194, pp.181-189, 2001. ,
Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16, Mucosal Immunol, vol.5, pp.173-83, 2012. ,
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection, J Exp Med, vol.205, pp.323-332, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00227540
Antiviral agents for the treatment and chemoprophylaxis of influenza ---recommendations of the Advisory Committee on Immunization Practices (ACIP), MMWR Recomm Rep, vol.60, pp.1-24, 2011. ,
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract, Vaccine, vol.33, pp.3331-3372, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-01182907
Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis, Virol J, vol.6, p.67, 2009. ,
Antiviral resistance among highly pathogenic influenza A (H5N1) viruses isolated worldwide in 2002-2012 shows need for continued monitoring, Antiviral Res, vol.98, pp.297-304, 2013. ,
Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection, J Virol, vol.84, pp.7750-7759, 2010. ,
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats, Antiviral Res, vol.73, pp.1-11, 2007. ,
Modulating immunity as a therapy for bacterial infections, Nat Rev Microbiol, vol.10, pp.243-54, 2012. ,
Enhanced expression of an alpha2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor, J Clin Microbiol, vol.43, pp.4139-4185, 2005. ,
Targeting of Toll-like receptors: a decade of progress in combating infectious diseases, Lancet Infect Dis, vol.11, pp.702-714, 2011. ,
Influenza: lessons from past pandemics, warnings from current incidents, Nat Rev Microbiol, vol.3, pp.591-600, 2005. ,
Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice, PLoS One, vol.9, p.96165, 2014. ,
Distinct patterns of IFITMmediated restriction of filoviruses, SARS coronavirus, and influenza A virus, PLoS Pathog, vol.7, 2011. ,
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection, J Virol, vol.87, pp.6911-6935, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00926618
Innate immunity to influenza virus infection, Nat Rev Immunol, vol.14, pp.315-343, 2014. ,
Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis, Infect Immun, vol.79, pp.1498-503, 2011. ,
CpG oligodeoxynucleotides protect against the 2009 H1N1 pandemic influenza virus infection in a murine model, Antiviral Res, vol.89, pp.124-130, 2011. ,
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat Immunol, vol.11, pp.373-84, 2010. ,
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycinresistant Enterococcus infection, J Infect Dis, vol.201, pp.534-577, 2010. ,
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense, Immunity, vol.36, pp.276-87, 2012. ,
Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice, Virology, vol.406, pp.80-87, 2010. ,
Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir, Eur J Pharmacol, vol.818, pp.191-197, 2018. ,
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses, Proc Natl Acad Sci U S A, vol.104, pp.1371-1377, 2007. ,
Interferoninducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol, Immunity, vol.38, pp.92-105, 2013. ,
Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection, PLoS One, vol.12, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01605882
TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease. Front Immunol 5, 79, 1006. ,
Mapping the pulmonary environment of animals protected from virulent H1N1 influenza infection using the TLR-2 agonist Pam(2)Cys, Immunol Cell Biol, vol.94, pp.169-76, 2016. ,
The antiviral activities of ISG15, J Mol Biol, vol.425, pp.4995-5008, 2013. ,
Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses, PLoS Pathog, vol.4, p.1000151, 2008. ,
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection, Infect Immun, vol.78, pp.4226-4259, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00520159
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity, J Immunol, vol.181, pp.2036-2079, 2008. ,
Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model, J Virol, vol.84, pp.2983-95, 2010. ,
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages, J Biol Chem, vol.287, pp.8816-8845, 2012. ,
, A Toll-Like Receptor, vol.5, 2015.
, Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza VirusAssociated Pneumococcal Mouse Infections, Antimicrob Agents Chemother, vol.59, pp.6064-72
Influenza virus assembly and budding, Virology, vol.411, pp.229-265, 2011. ,
Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases, Front Immunol, vol.4, p.387, 2013. ,
Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice, Mol Pharm, vol.9, pp.2710-2718, 2012. ,
Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia, 1117. ,
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa, J Immunol, vol.185, pp.1177-85, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00495564
,
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity, Mucosal Immunol, vol.7, pp.489-500, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-00925663
Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection, J Infect Dis, vol.210, pp.493-503, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-01182903
Compartmentalized Antimicrobial Defenses in Response to Flagellin, Trends Microbiol, vol.26, pp.423-435, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-01671191
Host Cell Restriction Factors that Limit Influenza A Infection, 2017. ,
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts, Cell Host Microbe, vol.2, pp.96-105, 2007. ,
Activation of toll-like receptor signaling pathway for protection against influenza virus infection, Vaccine, vol.27, pp.3481-3484, 2009. ,
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand, Proc Natl Acad Sci U S A, vol.104, pp.3990-3995, 2007. ,
Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide, J Immunol, vol.185, pp.1142-1151, 2010. ,
Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18, Science, vol.346, pp.861-866, 1122. ,
URL : https://hal.archives-ouvertes.fr/hal-01290555
Intranasal treatment with poly(I*C) protects aged mice from lethal respiratory virus infections, J Virol, vol.86, pp.11416-11440, 1353. ,
Twelve hours before infection and 12 and 36h post-infection, mice received 5 µg of flagellin intraperitoneally. Lungs were sampled 24 and 48 h post-infection (12h post-flagellin administration) and mRNA was quantified by RT-qPCR. (B, D) The relative gene expression was normalized to the expression of PBS-treated animals (arbitrarily set to a value of 1. Results are represented as the median with standard deviation, Supplementary figure Supplementary figure: Flagellin treatment does not activate expression of IL-18 encoding gene ,