Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease

Sandrine Le Guellec (1, 2, 3) , Laurine Allimonnier (2, 1) , Nathalie Heuzé-Vourc'H (4, 5, 6) , Maria Cabrera (4) , Frédéric Ossant (7) , Jérémie Pourchez (8) , Laurent Vecellio (2, 1) , Laurent Plantier (9, 1)

1 CEPR - Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100
2 UT - Université de Tours
3 DTF-Aerodrug
4 PRPA - Pathologies Respiratoires : Protéolyse et Aérosolthérapie
5 Université Francois Rabelais [Tours]
6 INSERM - Institut National de la Santé et de la Recherche Médicale
7 iBraiN - Imaging, Brain & Neuropsychiatry
8 SAINBIOSE - Santé Ingénierie Biologie Saint-Etienne
9 CHU Trousseau [Tours]

Mots clés: Pulmonary fibrosis; nebulization; physiology; compliance; aerosol; inhalation

Domaines: Médecine humaine et pathologie

Sandrine Le Guellec, Laurine Allimonnier, Nathalie Heuzé-Vourc'H, Maria Cabrera, Frédéric Ossant, et al.. Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease. Frontiers in Bioengineering and Biotechnology, 2020, 8, ⟨10.3389/fbioe.2020.01022⟩. ⟨hal-03687289⟩