Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals - Archive ouverte HAL Access content directly
Journal Articles Advanced Drug Delivery Reviews Year : 2020

Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals

(1) , (1) , (1) , (1)
1

Abstract

Nonclinical studies are fundamental for the development of inhaled drugs, as for any drug product, and for successful translation to clinical practice. They include in silico, in vitro, ex vivo and in vivo studies and are intended to provide a comprehensive understanding of the inhaled drug beneficial and detrimental effects. To date, animal models cannot be circumvented during drug development programs, acting as surrogates of humans to predict inhaled drug response, fate and toxicity. Herein, we review the animal models used during the different development stages of inhaled pharmaceuticals and biopharmaceuticals, highlighting their strengths and limitations.
Fichier principal
Vignette du fichier
10.1016-j.addr.2020.06.029_Secher_et_al_2020.pdf (621.89 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03687170 , version 1 (03-06-2022)

Identifiers

Cite

T. Sécher, E. Bodier-Montagutelli, A. Guillon, N. Heuzé-Vourc’h. Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals. Advanced Drug Delivery Reviews, 2020, 167, pp.148-169. ⟨10.1016/j.addr.2020.06.029⟩. ⟨hal-03687170⟩
21 View
21 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More