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Journal Articles Cancers Year : 2021

Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors

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Abstract

The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.

Dates and versions

hal-03557339 , version 1 (04-02-2022)

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Emilie Barsac, Carolina de Amat Herbozo, Loïc Gonzalez, Thomas Baranek, Thierry Mallevaey, et al.. Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors. Cancers, 2021, 13 (14), pp.3578. ⟨10.3390/cancers13143578⟩. ⟨hal-03557339⟩
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