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Article Dans Une Revue Cancers Année : 2021

Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors

Résumé

The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.

Domaines

Immunologie

Dates et versions

hal-03518733 , version 1 (10-01-2022)

Identifiants

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Emilie Barsac, Carolina de Amat Herbozo, Loïc Gonzalez, Thomas Baranek, Thierry Mallevaey, et al.. Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors. Cancers, 2021, 13 (14), pp.3578. ⟨10.3390/cancers13143578⟩. ⟨hal-03518733⟩

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