Change in the regulatory framework for zolpidem

What is the impact on the landscape of the prescription of sedative medications? The French national ZORRO study

Marion Istvan (1) , Pascal Caillet , Morgane Rousselet (1) , Marylène Guerlais , Edouard-Jules Laforgue , Marie Gérardin , Pascale Jolliet (1) , Fanny Feuillet (1) , Caroline Victorri-Vigneau (1)

1 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch

In recent years, zolpidem has been the subject of numerous reports of misuse, abuse and dependence. In view of these risks, the French drug agency (ANSM) decreed in April 2017 the implementation of secure prescription pads. The objective of this study was to evaluate the impact of this regulatory measure on the prescription of zolpidem and other sedative medications (zopiclone, benzodiazepines and antihistamines) in long-term users of zolpidem and associated factors.

Mots clés: benzodiazepines; hypnotics; pharmacoepidemiology; sedatives; state sequence analysis; zolpidem

Domaines: Sciences du Vivant [q-bio]

Marion Istvan, Pascal Caillet, Morgane Rousselet, Marylène Guerlais, Edouard-Jules Laforgue, et al.. Change in the regulatory framework for zolpidem. British Journal of Clinical Pharmacology, 2021, 87 (8), pp.3310-3319. ⟨10.1111/bcp.14753⟩. ⟨hal-03407064⟩