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Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients

Abstract : COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19–driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, we serially analyzed unconventional T cells, a heterogeneous class of T lymphocytes (MAIT, γδT, and iNKT cells) with potent antimicrobial and regulatory functions. Circulating unconventional T cells of COVID-19 patients presented with a profound and persistent phenotypic alteration. In the airways, highly activated unconventional T cells were detected, suggesting a potential contribution in the regulation of local inflammation. Finally, expression of the CD69 activation marker on blood iNKT and MAIT cells of COVID-19 patients on admission was predictive of clinical course and disease severity. Thus, COVID-19 patients present with an altered unconventional T cell biology, and further investigations will be required to precisely assess their functions during SARS–CoV-2–driven ARDS.
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https://hal-univ-tours.archives-ouvertes.fr/hal-03365046
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Submitted on : Tuesday, October 5, 2021 - 10:15:26 AM
Last modification on : Wednesday, October 20, 2021 - 1:31:12 AM

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Youenn Jouan, Antoine Guillon, Loïc Gonzalez, Yonatan Perez, Chloé Boisseau, et al.. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (12), ⟨10.1084/jem.20200872⟩. ⟨hal-03365046⟩

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