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Journal articles
Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors
Abstract : The vast majority of studies on T cell biology in tumor immunity have focused on peptide-reactive conventional T cells that are restricted to polymorphic major histocompatibility complex molecules. However, emerging evidence indicated that unconventional T cells, including γδ T cells, natural killer T (NKT) cells and mucosal-associated invariant T (MAIT) cells are also involved in tumor immunity. Unconventional T cells span the innate–adaptive continuum and possess the unique ability to rapidly react to nonpeptide antigens via their conserved T cell receptors (TCRs) and/or to activating cytokines to orchestrate many aspects of the immune response. Since unconventional T cell lineages comprise discrete functional subsets, they can mediate both anti- and protumoral activities. Here, we review the current understanding of the functions and regulatory mechanisms of protumoral unconventional T cell subsets in the tumor environment. We also discuss the therapeutic potential of these deleterious subsets in solid cancers and why further feasibility studies are warranted.
https://hal-univ-tours.archives-ouvertes.fr/hal-03365028
Contributor : Christophe Paget Connect in order to contact the contributor
Submitted on : Tuesday, October 5, 2021 - 10:10:26 AM
Last modification on : Wednesday, October 6, 2021 - 9:47:00 AM
Contributor : Christophe Paget Connect in order to contact the contributor
Submitted on : Tuesday, October 5, 2021 - 10:10:26 AM
Last modification on : Wednesday, October 6, 2021 - 9:47:00 AM
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