Skip to Main content Skip to Navigation
Journal articles

TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration

Abstract : In prostate carcinogenesis, androgens are known to control the expression of the transient receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR). Overexpression and/or activity of TRPM8 channel was shown to suppress prostate cancer (PCa) cell migration. Here we report that at certain concentrations androgens facilitate PCa cell migration. We show that underlying mechanism is inhibition of TRPM8 by activated AR which interacts with the channel within lipid rafts microdomains of the plasma membrane. Thus, our study has identified an additional nongenomic mechanism of the TRPM8 channel regulation by androgens that should be taken into account upon the development of novel therapeutic strategies.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03133861
Contributor : Collection IEMN Connect in order to contact the contributor
Submitted on : Monday, May 23, 2022 - 4:03:15 PM
Last modification on : Tuesday, May 24, 2022 - 3:19:27 PM

File

Grolez_2019_s41419-019-1891-8....
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Guillaume P. Grolez, Dmitri V. Gordiendko, Manon Clarisse, Mehdi Hammadi, Emilie Desruelles, et al.. TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration. Cell Death and Disease, Nature Publishing Group, 2019, 10 (9), pp.652. ⟨10.1038/s41419-019-1891-8⟩. ⟨hal-03133861⟩

Share

Metrics

Record views

39

Files downloads

0