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Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential

Abstract : Grape canes are waste biomass of viticulture containing bioactive polyphenols valuable in cosmetics. Whereas several studies reported the cosmetic activities of E-resveratrol, only few described the potential of E-epsilon-viniferin, the second major constituent of grape cane extracts (GCE), and none of them investigated GCE as a natural blend of polyphenols for cosmetic applications. In this study, we considered the potential of GCE from polyphenol-rich grape varieties as multifunctional cosmetic ingredients. HPLC analysis was performed to quantify major polyphenols in GCE i.e., catechin, epicatechin, E-resveratrol, E-piceatannol, ampelopsin A, E-epsilon-viniferin, hopeaphenol, isohopeaphenol, E-miyabenol C and E-vitisin B from selected cultivars. Skin whitening potential through tyrosinase inhibition assay and the activation capacity of cell longevity protein (SIRT1) of GCE were compared to pure E-resveratrol and E-epsilon-viniferin. Drug-likeness of GCE polyphenols were calculated, allowing the prediction of skin permeability and bioavailability. Finally, the present data enabled the consideration of GCE from polyphenol-rich varieties as multifunctional cosmetic ingredients in accordance with green chemistry practices.
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https://hal-univ-tours.archives-ouvertes.fr/hal-03115827
Contributor : Sébastien Besseau Connect in order to contact the contributor
Submitted on : Monday, October 18, 2021 - 11:51:57 AM
Last modification on : Tuesday, January 11, 2022 - 5:56:07 PM
Long-term archiving on: : Wednesday, January 19, 2022 - 8:26:03 PM

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Magdalena Anna Malinowska, Kévin Billet, Samantha Drouet, Thibaut Munsch, Marianne Unlubayir, et al.. Grape Cane Extracts as Multifunctional Rejuvenating Cosmetic Ingredient: Evaluation of Sirtuin Activity, Tyrosinase Inhibition and Bioavailability Potential. Molecules, MDPI, 2020, 25 (9), pp.2203. ⟨10.3390/molecules25092203⟩. ⟨hal-03115827⟩

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