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Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration

Abstract : Ommochromes are widespread pigments that mediate multiple functions in invertebrates. The two main families of ommochromes are ommatins and ommins, which both originate from the kynurenine pathway but differ in their backbone, thereby in their coloration and function. Despite its broad significance, how the structural diversity of ommochromes arises in vivo has remained an open question since their first description. In this study, we combined organic synthesis, analytical chemistry and organelle purification to address this issue. From a set of synthesized ommatins, we derived a fragmentation pattern that helped elucidating the structure of new ommochromes. We identified uncyclized xanthommatin as the elusive biological intermediate that links the kynurenine pathway to the ommatin pathway within ommochromasomes, the ommochrome-producing organelles. Due to its unique structure, we propose that uncyclized xanthommatin functions as a key branching metabolite in the biosynthesis and structural diversification of ommatins and ommins, from insects to cephalopods.
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Submitted on : Monday, August 22, 2022 - 1:51:37 PM
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Florent Figon, Thibaut Munsch, Cecile Croix, Marie-Claude Viaud-Massuard, Arnaud Lanoue, et al.. Uncyclized xanthommatin is a key ommochrome intermediate in invertebrate coloration. Insect Biochemistry and Molecular Biology, Elsevier, 2020, 124, pp.103403. ⟨10.1016/j.ibmb.2020.103403⟩. ⟨hal-02886293⟩



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