, Human Skin Cells. J. Agric. Life Sci, vol.49, pp.125-135

,

Z. Liu, S. Chen, Y. Zhou, C. Xie, B. Zhu et al., , p.622

Y. , Deciphering the venomic transcriptome of killer-wasp Vespa velutina, 2015.

, Sci Rep, vol.5, p.9454

R. M. Lobayan and M. C. Schmit, Conformational and NBO studies of serotonin 625 as a radical scavenger. Changes induced by the OH group, J Mol Graph Model, vol.626, pp.224-237, 2018.

Y. Lu, T. J. Khoo, and C. Wiart, Antioxidant Activity Determination of Citronellal 628 and Crude Extracts of Cymbopogon citratus by 3 Different Methods. Pharmacol 629 Pharm 05, pp.395-400, 2014.

K. Monceau, O. Bonnard, and D. Thiéry, Vespa velutina: a new invasive predator 631 of honeybees in Europe, J Pest Sci, vol.87, pp.1-16, 2014.

M. Morais, L. Moreira, X. Feás, and L. M. Estevinho, Honeybee-collected pollen 634 from five Portuguese Natural Parks: Palynological origin, phenolic content, 635 antioxidant properties and antimicrobial activity, Food Chem. Toxicol, vol.49, pp.1096-636, 2011.

. Neda, P. Vlazan, R. Oana, P. Sfarloaga, I. Grozescu et al., 638 proteomic approach, Biochim. Biophys. Acta, vol.1752, pp.1-5, 2012.

,

T. Piek, Venoms of the Hymenoptera: Biochemical, p.646, 2013.

, Behavioural Aspects

T. Quan and G. J. Fisher, Role of Age-Associated Alterations of the Dermal 648, 2015.

, Extracellular Matrix Microenvironment in Human Skin Aging. Gerontology, vol.61, pp.649-427

N. Surendra, G. Jayaram, and M. Reddy, Antimicrobial activity of crude 651 venom extracts in honeybees (Apis cerana, Apis dorsata, Apis florea) tested 652 against selected pathogens, Afr. J. Microbiol. Res, vol.5, pp.2765-2772, 2011.

,

A. Sadiq, A. Shah, M. G. Jeschke, C. Belo, M. Qasim-hayat et al.,

S. , The Role of Serotonin during Skin Healing in Post-Thermal Injury, 2018.

, J Mol Sci, vol.19

R. A. Sansone and L. A. Sansone, Sunshine, Serotonin, and Skin: A Partial 658 Explanation for Seasonal Patterns in Psychopathology?, Innov Clin Neurosci, vol.10, pp.20-24, 2013.

P. Sharma, A. B. Jha, R. S. Dubey, and M. Pessarakli, , p.661, 2012.

, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under

.. J. Stressful-conditions and . Bot, , vol.26, 2012.

W. Shi, S. Zhang, C. Zhang, and J. Cheng, Cloning and comparative 664 analysis of the venom prepromelittin genes from four wasp species, The FASEB Journal, vol.16, pp.896-898, 2002.

F. Sobral, A. Sampaio, S. Falcão, M. J. Queiroz, and R. C. Calhelha,

M. Ferreira and I. C. , Chemical characterization, antioxidant, anti-672 inflammatory and cytotoxic properties of bee venom collected in Northeast 673 Portugal, Food Chem. Toxicol, vol.94, pp.172-177, 2016.

,

S. Somwongin, P. Chantawannakul, and W. Chaiyana, Antioxidant activity and 676 irritation property of venoms from Apis species, Toxicon, vol.145, pp.32-39, 2018.

,

N. Sookrung, S. Wong-din-dam, A. Tungtrongchitr, O. Reamtong, and . Indrawattana, , p.679

N. Sakolvaree, Y. Visitsunthorn, N. Manuyakorn, W. Chaicumpa, and W. , , 2014.

, Proteome and allergenome of Asian wasp, Vespa affinis, venom and IgE 681 reactivity of the venom components, J. Proteome Res, vol.13, pp.1336-1344

,

Z. Su-fang, S. H. Wan-jun, C. Jia-an, and Z. Chuan-xi, Cloning and 684 Comparison of the Genes Encoding Preproapamin from the Venom of 2, 2003.

, Honeybee and 4 Wasp Species, Insect Sci, vol.10, pp.21-26

,

M. Verdoni, H. Roudaut, H. De-pomyers, D. Gigmes, D. Bertin et al., Clustering, and Protein Extraction for Serum Profiling with Mass Spectrometry

, Anal. Chem, vol.78, pp.743-752

A. Weisel-eichler and F. Libersat, Venom effects on monoaminergic systems, 2004.

, Comp Physiol A, vol.190, pp.683-690

M. J. Yang, W. Lin, K. Lu, and W. Tu, Evaluating antioxidative activities 698 of amino acid substitutions on mastoparan-B, Peptides, vol.32, pp.2037-2043, 2011.

,

Y. Yang, H. Huang, Z. Xu, and J. Duan, Serotonin and Its Receptor as a New 701, 2017.

, Antioxidant Therapeutic Target for Diabetic Kidney Disease, J Diabetes Res, vol.702, 2017.

Y. Zhang, R. Chen, H. Ma, and S. Chen, Isolation and Identification of Dipeptidyl 704, 2015.

, Peptidase IV-Inhibitory Peptides from Trypsin/Chymotrypsin-Treated Goat Milk

C. Hydrolysates-by-2d-tlc and L. , J. Agric. Food Chem, vol.63, pp.8819-8828

C. Zhu, W. Zhang, G. Zhou, X. Xu, Z. Kang et al., Isolation 708 and Identification of Antioxidant Peptides from Jinhua Ham, J. Agric. Food, 2013.

, This peak is not present in the non-active 744 fraction (F9). (B) Mass spectrum of coincident peak at the t r = 0, Chem, vol.61, pp.1265-1271

, A) MS/MS profile at the collision 746 energy 30 eV of m/z 177.1022 of serotonin (upper spectrum) and active fraction F2 747 (lower spectrum). (B) Primary chemical structure of serotonin, Figure, vol.5

, Antioxidant activity of serotonin. (A) Dose-response curve of serotonin 750 in DPPH scavenging activity assay measured at 515 nm, results are expressed as, Figure, vol.6

±. Mean and . Sd, RSA: Radical scavenging activity. IC 50 was calculated by Graphpad 752

, B) XTT cytotoxicity assay of serotonin in HaCaT cells for 48h. Results are 753 expressed as Mean ± SD, n=3. NT: Non-treated cells *: significant discrimination 754 versus non-treated group at p<0.05 in ANOVA test (R software). (C) Reactive oxygen 755 species (ROS) reduction effect of serotonin in HaCaT cells irradiated by UVB

, Results are expressed as Mean ± SD, n=3. T+: HaCaT cell irradiated by UVB without 757 adding venom. NT: Non-treated cells *: significant discrimination versus T+ group at 758 p<0