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Journal articles
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes
Abstract : Cyclization reactions that create complex polycyclic scaffolds are hallmarks of alkaloid biosynthetic pathways. We present the discovery of three homologous cytochrome P450s from three monoterpene indole alkaloid-producing plants (Rauwolfia serpentina, Gelsemium sempervirens and Catharanthus roseus) that provide entry into two distinct alkaloid classes, the sarpagans and the β-carbolines. Our results highlight how a common enzymatic mechanism, guided by related but structurally distinct substrates, leads to either cyclization or aromatization.
https://hal-univ-tours.archives-ouvertes.fr/hal-02527530
Contributor : Sébastien Besseau <>
Submitted on : Wednesday, April 1, 2020 - 11:29:16 AM
Last modification on : Saturday, April 25, 2020 - 2:26:55 PM
Contributor : Sébastien Besseau <>
Submitted on : Wednesday, April 1, 2020 - 11:29:16 AM
Last modification on : Saturday, April 25, 2020 - 2:26:55 PM
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