Significant need for a French network of Expert Centers Enabling a Better Characterization and Management of treatment-resistant depression (Fondation FondaMental)

Antoine Yrondi (1) , Djamila Bennabi (2) , Emmanuel Haffen (2) , Marion Garnier , Frank Bellivier (3) , Thierry Bourgerol (4) , Vincent Camus (5) , Thierry d'Amato , Olivier Doumy (6) , Frédéric Haesebaert (7) , Jérôme Holtzmann (7) , Christophe Lançon (8) , Philippe Vignaud , Fanny Moliere (9) , Isabel Nieto (7) , Raphaelle Richieri , Philippe Domenech (10) , Corentin Rabu (11) , Luc Mallet (12) , Liova Yon (3) , Laurent Schmitt , Florian Stephan , Guillaume Vaiva (13) , Michel Walter (14) , Pierre-Michel Llorca (7) , Philippe Courtet (9) , Marion Leboyer (3) , Wissam El-Hage (15) , Bruno Aouizerate (7)

1 ToNIC - Toulouse Neuro Imaging Center
2 UBFC - Université Bourgogne Franche-Comté [COMUE]
3 IMRB - Institut Mondor de Recherche Biomédicale
4 CHU Grenoble
5 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
6 Hôpital Charles Perrens
7 Fondation FondaMental [Créteil]
8 SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants
9 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
10 ISC - Institut des Sciences Cognitives
11 Hôpital Henri Mondor
12 Neurologie et thérapeutique expérimentale
13 SCALab - Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193
14 CHU - Brest- Psychiatrie - CHRU Brest - Psychiatrie Adulte
15 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau

Background: Major depression is characterized by (i) a high lifetime prevalence of 16-17% in the general population; (ii) a high frequency of treatment resistance in around 20-30% of cases; (iii) a recurrent or chronic course; (iv) a negative impact on the general functioning and quality of life; and (v) a high level of comorbidity with various psychiatric and non-psychiatric disorders, high occurrence of completed suicide, significant burden along with the personal, societal, and economic costs. In this context, there is an important need for the development of a network of expert centers for treatment-resistant depression (TRD), as performed under the leadership of the Fondation FondaMental.

Domains: Life Sciences [q-bio]; Human health and pathology; Psychiatrics and mental health

Antoine Yrondi, Djamila Bennabi, Emmanuel Haffen, Marion Garnier, Frank Bellivier, et al.. Significant need for a French network of Expert Centers Enabling a Better Characterization and Management of treatment-resistant depression (Fondation FondaMental). Frontiers in Psychiatry, 2017, 8, ⟨10.3389/fpsyt.2017.00244⟩. ⟨hal-02524187⟩