Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental)

D. Bennabi , A. Yrondi , T. Charpeaud , J.-B. Genty (1) , S. Destouches , S. Lancrenon (2) , N. Allaili , F. Bellivier (3) , T. Bougerol (3) , V. Camus (4) , O. Doumy , J.-M. Dorey (3) , F. Haesebaert , J. Holtzmann , C. Lançon (5) , F. Moliere , I. Nieto , C. Rabu , R. Richieri (6) , L. Schmitt (7) , F. Stephan (8) , G. Vaiva (9) , M. Walter , M. Leboyer (3) , Wissam El-Hage (10) , Bruno Aouizerate (3) , E. Haffen (11) , P.-M. Llorca (3) , P. Courtet (12)

1 CEP - Centre d'expertise de la performance Gilles Cometti [Dijon]
2 Sylia Stat Lancrenon S.A.S.
3 Fondation FondaMental [Créteil]
4 GPL - Groupe d'étude des proliférations lymphoïdes
5 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
6 Departement de Psychiatrie
7 ERL 6230
8 DESY - Deutsches Elektronen-Synchrotron [Zeuthen]
9 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies
10 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau
11 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
12 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

Background: Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking. Method: The French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of depression based on the RAND/ UCLA Appropriatneness Method. Recommendations for lines of treatment are provided by the scientific committee after data analysis and interpretation of the results of a survey of 36 psychiatrist experts in the field of major depression and its treatments. Results: The expert guidelines combine scientific evidence and expert clinician's opinion to produce recommendations for major depression with comorbid anxiety disorders, personality disorders or substance use disorders and in geriatric depression. Conclusion: These guidelines provide direction addressing common clinical dilemmas that arise in the pharmacologic treatment of major depression with comorbid psychiatric conditions.

Keywords: Anxiety disorders; Elderly; Major depressive disorder; Pharmacotherapy

Keywords: Substance use disorders

Domains: Life Sciences [q-bio]; Human health and pathology; Psychiatrics and mental health

D. Bennabi, A. Yrondi, T. Charpeaud, J.-B. Genty, S. Destouches, et al.. Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental). BMC Psychiatry, 2019, 19 (1), pp.1-9. ⟨10.1186/s12888-019-2025-7⟩. ⟨hal-02524126⟩