Trauma reactivation under propranolol among traumatized Syrian refugee children: preliminary evidence regarding efficacy - Université de Tours Accéder directement au contenu
Article Dans Une Revue European Journal of Psychotraumatology Année : 2020

Trauma reactivation under propranolol among traumatized Syrian refugee children: preliminary evidence regarding efficacy

Résumé

Background: There is a dearth of therapeutic solutions for traumatized young patients. Trauma reactivation conducted under the influence of the reconsolidation blocker propra-nolol (Reconsolidation Therapy) is a simple, cost-effective treatment option that has some promising initial results in adults suffering from posttraumatic stress disorder (PTSD). Objective: To explore the usefulness of this novel treatment in children. The primary outcome was the reduction of PTSD symptoms at the end of treatment, while secondary outcomes included reduction in anxiety and in depressive symptoms. Method: An open-label clinical trial was conducted in a refugee camp in Syria, investigating the safety and efficacy of this therapeutic strategy in 117 children suffering from enduring PTSD symptoms. Participants received propranolol 90 minutes before briefly recalling (i.e. reactivating) a single personal traumatic memory, for 5 consecutive days. Self-reported anxiety, depressive, and PTSD symptoms were assessed at baseline, as well as 4 and 13 weeks after treatment. Results: A significant, clinically meaningful symptom reduction was observed at all post-treatment measurement times vs. baseline. More specifically, between baseline and the 13-week follow-up we observed a 64% PTSD symptoms reduction (d = 2.71). In a similar vein, we obtained a 39% symptoms reduction for depressive symptoms (d = 1.01). The general anxiety symptoms improved, but eventually returned to prior level, probably because of the deteriorating living conditions in the camp. Conclusions: This therapy appeared as a potentially safe and useful treatment strategy for children suffering from PTSD symptoms, warranting replication studies using stronger study designs. The social acceptability and ease of implementation of the treatment should also be noted.
Fichier principal
Vignette du fichier
2020_Thierrée_EJPT.pdf (1.26 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02524087 , version 1 (30-03-2020)

Identifiants

Citer

Sarah Thierrée, Sami Richa, Alain Brunet, Laurine Egreteau, Quentin Roig, et al.. Trauma reactivation under propranolol among traumatized Syrian refugee children: preliminary evidence regarding efficacy. European Journal of Psychotraumatology , 2020, 11 (1), pp.1733248. ⟨10.1080/20008198.2020.1733248⟩. ⟨hal-02524087⟩
153 Consultations
178 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More