Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells - Archive ouverte HAL Access content directly
Journal Articles Journal of Biological Chemistry Year : 1995

Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells

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1
C. Pallard
  • Function : Author
M. Charon
  • Function : Author
B. Groner
  • Function : Author
S. Gisselbrecht
  • Function : Author
I. Dusanter-Fourt
  • Function : Author

Abstract

Interleukin-3 (IL-3)-, erythropoietin (EPO)-, and prolactin (PRL)-induced signal transduction via the JAK/STAT pathway was studied in the IL-3-dependent BAF-3 lymphoid cell line. Transfected cells expressing either the long form of the PRL receptor or the EPO receptor were used. We demonstrated that IL-3, EPO, and PRL activated a transcription factor related to the mammary transcription factor STAT5 but not to STAT1, -2, -3, or -4 as opposed to interferon gamma (IFN gamma) which activated STAT1 in the same cells. Similarly, PRL and EPO activated a STAT5-like factor (STAT5-L) in the rat Nb2 and the human UT7 cells expressing endogenous PRL and EPO receptors, respectively. The hematopoietic STAT5-L activated by IL-3, EPO, or PRL was identified as a 97-kDa tyrosine-phosphorylated protein. These results confer to STAT5 a much broader role than previously suggested.
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hal-02427576 , version 1 (02-11-2021)

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C. Pallard, F. Gouilleux, M. Charon, B. Groner, S. Gisselbrecht, et al.. Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells. Journal of Biological Chemistry, 1995, 270 (27), pp.15942-15945. ⟨10.1074/jbc.270.27.15942⟩. ⟨hal-02427576⟩

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