Activated Stat Related Transcription Factors in Acute Leukemia - Archive ouverte HAL Access content directly
Journal Articles Leukemia & lymphoma Year : 1997

Activated Stat Related Transcription Factors in Acute Leukemia

(1) , (1) , (1) , (1) , (1) , (1) , (1)
1
Valérie Gouilleux-Gruart
Fabrice Gouilleux
Lionel Prin
  • Function : Author

Abstract

Cell proliferation and differentiation are under the control of cytokines and growth factors. Different signaling pathways are involved in the transmission of a specific signal through successive phosphorylation and dephosphorylation of proteins leading to gene transcription necessary for growth and differentiation. The cytokines and growth factors activate the Stat family of transcription factors. The Jak-Stat pathway is essential for cytokine signal transduction. Dysregulation of this cascade might lead to uncontrolled hematopoiesis. Studies have been carried out to examine the functionality of this pathway in cells from patients with acute leukemia. Members of the Stat protein family (Stat1, Stat3 and Stat5) are constitutively activated in cells collected from some acute leukemias suggesting dysregulation of the Jak-Stat pathway. Evidence of the existence of constitutively activated spliced variants of Stat3 and Stat5 proteins are described. The mechanisms of such activation remain to be clarified.
Fichier principal
Vignette du fichier
Activated_Stat_Related_Transcription_Factors_in_Ac.pdf (4.73 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-02427398 , version 1 (05-11-2021)

Identifiers

Cite

Valérie Gouilleux-Gruart, Françoise Debierre-Grockiego, Fabrice Gouilleux, Jean-Claude Capiod, Jean-François Claisse, et al.. Activated Stat Related Transcription Factors in Acute Leukemia. Leukemia & lymphoma, 1997, 28 (1-2), pp.83-88. ⟨10.3109/10428199709058334⟩. ⟨hal-02427398⟩

Collections

INSERM UNIV-TOURS
20 View
47 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More