Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells - Archive ouverte HAL Access content directly
Journal Articles Biochimica et Biophysica Acta - Molecular Cell Research Year : 1998

Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells

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1
Roland Piekorz
  • Function : Author
Ralf Rinke
  • Function : Author
Brigitte Neumann
  • Function : Author
Bernd Groner
  • Function : Author
Gertrud Hocke
  • Function : Author

Abstract

Treatment of M1 myeloid leukemia cells with leukemia inhibitory factor (LIF) causes activation of transcription factors Stat1, Stat3 and Stat5a (signal transducers and activators of transcription). DNA-binding of Stat proteins was detectable for extended periods of time in LIF-treated M1 cells, which simultaneously underwent terminal differentiation. The relative composition of Stat factors in the protein-DNA complexes changed during time. Whereas Stat3 was activated up to 36 h during treatment with LIF, Stat5a was activated only short-termed. Similarly, high expression of the immediate early gene CIS (cytokine-inducible SH2-containing protein), a known target gene of Stat5 in hematopoietic cells, occurred only during the onset of differentiation. This suggests a role of Stat5a in the early phase of LIF-induced differentiation and growth arrest of M1 cells.
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Dates and versions

hal-02427392 , version 1 (04-11-2021)

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Roland Piekorz, Ralf Rinke, Fabrice Gouilleux, Brigitte Neumann, Bernd Groner, et al.. Modulation of the activation status of Stat5a during LIF-induced differentiation of M1 myeloid leukemia cells. Biochimica et Biophysica Acta - Molecular Cell Research, 1998, 1402 (3), pp.313-323. ⟨10.1016/s0167-4889(98)00024-x⟩. ⟨hal-02427392⟩

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