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Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein

Abstract : Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-kappaB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-kappaB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.
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https://hal-univ-tours.archives-ouvertes.fr/hal-02427356
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Submitted on : Friday, October 29, 2021 - 3:50:24 PM
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Susana Constantino Rosa Santos, Richard Monni, Isabelle Bouchaert, Olivier Bernard, Sylvie Gisselbrecht, et al.. Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein. FEBS Letters, Wiley, 2001, 497 (2-3), pp.148-152. ⟨10.1016/s0014-5793(01)02452-8⟩. ⟨hal-02427356⟩

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