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Journal articles
Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein
Abstract : Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-kappaB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-kappaB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.
https://hal-univ-tours.archives-ouvertes.fr/hal-02427356
Contributor : Fabrice Gouilleux <>
Submitted on : Friday, January 3, 2020 - 3:12:14 PM
Last modification on : Wednesday, June 24, 2020 - 3:11:13 AM
Contributor : Fabrice Gouilleux <>
Submitted on : Friday, January 3, 2020 - 3:12:14 PM
Last modification on : Wednesday, June 24, 2020 - 3:11:13 AM
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