Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein

Susana Constantino Rosa Santos , Richard Monni , Isabelle Bouchaert , Olivier Bernard (1) , Sylvie Gisselbrecht (2) , Fabrice Gouilleux (3) , Virginie Penard-Lacronique (4)

1 COMORE - Modeling and control of renewable resources
2 UMR_S567 / UMR 8104 - Institut Cochin
3 GICC UMR 6239 CNRS - Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
4 EMI 210 - Génétique des hémopathies humaines

Constitutively active tyrosine kinases are frequently expressed in various types of human leukemias as the result of chromosomal translocations. The TEL-Jak2 fusion oncoprotein possesses transforming properties in both animal and cellular models, that are tightly dependent on Stat5 activation. In the IL-3-independent TEL-Jak2-transformed Ba/F3 cells, activation of the PI-3K/Akt pathway appears essential to cell proliferation. Here we report a sustained activation of NF-kappaB factors in Ba/F3 cells, which inhibition dramatically impairs cell viability, indicating that NF-kappaB signaling exerts a major role in the anti-apoptotic activities of TEL-Jak2 oncoprotein.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cancer

Susana Constantino Rosa Santos, Richard Monni, Isabelle Bouchaert, Olivier Bernard, Sylvie Gisselbrecht, et al.. Involvement of the NF-κB pathway in the transforming properties of the TEL-Jak2 leukemogenic fusion protein. FEBS Letters, 2001, 497 (2-3), pp.148-152. ⟨10.1016/s0014-5793(01)02452-8⟩. ⟨hal-02427356⟩