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4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members

Juliette Gauduchon 1 Fabrice Gouilleux 2 Sébastien Maillard Véronique Marsaud 1 Jack-Michel Renoir 3 Brigitte Sola 4
1 PCPB - Physico-chimie, pharmacotechnie, biopharmacie
2 GICC UMR 6239 CNRS - Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
3 UP11 - Université Paris-Sud - Paris 11
4 MILPAT - Microenvironnement cellulaire et pathologie
Abstract : Cultured multiple myeloma cells were treated with various 4-OHT concentrations and the cellular response was studied: cell proliferation, cell viability, induction of apoptosis, caspase activities, and expression of signaling proteins.
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https://hal-univ-tours.archives-ouvertes.fr/hal-02427343
Contributor : Fabrice Gouilleux <>
Submitted on : Friday, January 3, 2020 - 3:01:28 PM
Last modification on : Wednesday, September 16, 2020 - 5:16:20 PM

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Juliette Gauduchon, Fabrice Gouilleux, Sébastien Maillard, Véronique Marsaud, Jack-Michel Renoir, et al.. 4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members. Clinical Cancer Research, American Association for Cancer Research, 2005, 11 (6), pp.2345-2354. ⟨10.1158/1078-0432.CCR-04-1668⟩. ⟨hal-02427343⟩

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