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4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members

Abstract : Cultured multiple myeloma cells were treated with various 4-OHT concentrations and the cellular response was studied: cell proliferation, cell viability, induction of apoptosis, caspase activities, and expression of signaling proteins.
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https://hal-univ-tours.archives-ouvertes.fr/hal-02427343
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Submitted on : Saturday, October 30, 2021 - 10:04:26 AM
Last modification on : Tuesday, January 11, 2022 - 5:56:33 PM

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Juliette Gauduchon, Fabrice Gouilleux, Sébastien Maillard, Véronique Marsaud, Jack-Michel Renoir, et al.. 4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members. Clinical Cancer Research, American Association for Cancer Research, 2005, 11 (6), pp.2345-2354. ⟨10.1158/1078-0432.CCR-04-1668⟩. ⟨hal-02427343⟩

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