4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members - Archive ouverte HAL Access content directly
Journal Articles Clinical Cancer Research Year : 2005

4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members

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Abstract

Cultured multiple myeloma cells were treated with various 4-OHT concentrations and the cellular response was studied: cell proliferation, cell viability, induction of apoptosis, caspase activities, and expression of signaling proteins.
Multiple myeloma is an incurable B-cell malignancy requiring new therapeutic strategies. Our approach was to analyze the in vitro effects of a selective estrogen receptor modulator, 4-hydroxytamoxifen (4-OHT), on six multiple myeloma cell lines.
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hal-02427343 , version 1 (30-10-2021)

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Juliette Gauduchon, Fabrice Gouilleux, Sébastien Maillard, Véronique Marsaud, Jack-Michel Renoir, et al.. 4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members. Clinical Cancer Research, 2005, 11 (6), pp.2345-2354. ⟨10.1158/1078-0432.CCR-04-1668⟩. ⟨hal-02427343⟩
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