The neonatal Fc receptor does not modulate hepatitis C virus neutralization - Université de Tours Accéder directement au contenu
Article Dans Une Revue Journal of General Virology Année : 2015

The neonatal Fc receptor does not modulate hepatitis C virus neutralization

Résumé

The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.

Dates et versions

hal-02425489 , version 1 (30-12-2019)

Identifiants

Citer

Anthony Morel, Christophe Passot, Christophe Arnoult, Amélie Dumans, Elodie Beaumont, et al.. The neonatal Fc receptor does not modulate hepatitis C virus neutralization. Journal of General Virology, 2015, 96 (5), pp.1062-1066. ⟨10.1099/vir.0.000060⟩. ⟨hal-02425489⟩
59 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More