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Journal Articles Journal of General Virology Year : 2015

The neonatal Fc receptor does not modulate hepatitis C virus neutralization

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Abstract

The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.

Dates and versions

hal-02425489 , version 1 (30-12-2019)

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Anthony Morel, Christophe Passot, Christophe Arnoult, Amélie Dumans, Elodie Beaumont, et al.. The neonatal Fc receptor does not modulate hepatitis C virus neutralization. Journal of General Virology, 2015, 96 (5), pp.1062-1066. ⟨10.1099/vir.0.000060⟩. ⟨hal-02425489⟩
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