Skip to Main content Skip to Navigation
Journal articles

Multi-drug resistance mediated by P-glycoprotein overexpression is not correlated with ZAP-70/CD38 expression in B-cell chronic lymphocytic leukemia

Abstract : ZAP-70 and CD38 expression can identify B-cell chronic lymphocytic leukemia with an inferior clinical outcome. Many groups have investigated the meaning of the expression of these two proteins and the correlation with the bad prognosis in B-CLL. But nobody has investigated the relation between the multidrug resistance mediated by Pgp overexpression (MDR1) and ZAP-70/CD38 coexpression. Forty-one untreated and stage A patients, either ZAP-70(+)CD38(+) or ZAP-70(-)CD38(-), were tested to determine the MDR1 status. MDR1 was observed in 41% of CLL ZAP-70(+)CD38(+) and in 37% of CLL ZAP-70(-)CD38(-). The difference was not significant (p = 0.745). Patients with ZAP-70 and CD38 positive CLL can not be candidates for MDR1 antagonists.
Document type :
Journal articles
Complete list of metadatas

https://hal-univ-tours.archives-ouvertes.fr/hal-02425408
Contributor : Valérie Gouilleux <>
Submitted on : Monday, December 30, 2019 - 2:35:48 PM
Last modification on : Wednesday, July 8, 2020 - 12:44:04 PM

Identifiers

Citation

Nicolas Guillaume, Valérie Gouilleux-Gruart, Jean-François Claisse, Xavier Troussard, Pascale Lepelley, et al.. Multi-drug resistance mediated by P-glycoprotein overexpression is not correlated with ZAP-70/CD38 expression in B-cell chronic lymphocytic leukemia. Leukemia & lymphoma, Taylor & Francis, 2009, 48 (8), pp.1556-1560. ⟨10.1080/10428190701457931⟩. ⟨hal-02425408⟩

Share

Metrics

Record views

267