Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade - Archive ouverte HAL Access content directly
Journal Articles Blood Year : 2008

Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

, (1) , , (2) , , (3) , (4) , , (5) , (6) , (7) , (8) , (8) , (5) , (2) , (9) , (6)
1
2
3
4
5
6
7
8
9
Noria Harir
  • Function : Author
Katrin Friedbichler
  • Function : Author
Rudin Kondo
  • Function : Author
Marc Kerenyi
  • Function : Author
Laurence Bénit
  • Function : Author
  • PersonId : 931601
Isabelle Dusanter-Fourt
  • Function : Author
  • PersonId : 900035

Abstract

The D816V-mutated variant of Kit triggers multiple signaling pathways and is considered essential for malignant transformation in mast cell (MC) neoplasms. We here describe that constitutive activation of the Stat5-PI3K-Akt-cascade controls neoplastic MC development. Retrovirally transduced active Stat5 (cS5F) was found to trigger PI3K and Akt activation, and to transform murine bone marrow progenitors into tissue-infiltrating MCs. Primary neoplastic Kit D816V+ MCs in patients with mastocytosis also displayed activated Stat5, which was found to localize to the cytoplasm and to form a signaling complex with PI3K, with consecutive Akt activation. Finally, the knock-down of either Stat5 or Akt activity resulted in growth inhibition of neoplastic Kit D816V+ MCs. These data suggest that a downstream Stat5-PI3K-Akt signaling cascade is essential for Kit D816V-mediated growth and survival of neoplastic MCs
Fichier principal
Vignette du fichier
Oncogenic Kit controls neoplastic mast cell growth through a Stat5PI3-kinase.pdf (2.36 Mo) Télécharger le fichier
Origin : Explicit agreement for this submission

Dates and versions

hal-02424605 , version 1 (30-10-2021)

Identifiers

Cite

Noria Harir, Cedric Boudot, Katrin Friedbichler, Karoline Sonneck, Rudin Kondo, et al.. Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood, 2008, 112 (6), pp.2463-2473. ⟨10.1182/blood-2007-09-115477⟩. ⟨hal-02424605⟩
53 View
261 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More