[Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].

J. Moreau (1) , M. Bonneville (2) , A. Godard (3) , H Gascan , V Gruart , M Moore , J Soulillou

1 CGS - Centre de géochimie de la surface
2 Immunointervention dans les allo et xénotransplantations
3 AIB_ERN - Interreg

Alloreactive T-cell clones obtained from cells infiltrating a human rejected kidney graft were shown to produce upon specific antigenic stimulation with interleukin 2, a factor triggering the proliferation of an interleukin 3 dependent murine cell line. The lymphokine responsible for this activity was a monomeric glycoprotein (MW = 41,000) exhibiting on one hand chemotactic as well as activating properties on murine and human eosinophils respectively, and on the other hand a burst promoting activity. Its biochemical and biological features strongly suggest that this factor cannot be likened to any known human lymphokine.

Domaines: Sciences du Vivant [q-bio]

J. Moreau, M. Bonneville, A. Godard, H Gascan, V Gruart, et al.. [Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1987, 304 (1), pp.5-10. ⟨hal-02414892⟩