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[Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].

Abstract : Alloreactive T-cell clones obtained from cells infiltrating a human rejected kidney graft were shown to produce upon specific antigenic stimulation with interleukin 2, a factor triggering the proliferation of an interleukin 3 dependent murine cell line. The lymphokine responsible for this activity was a monomeric glycoprotein (MW = 41,000) exhibiting on one hand chemotactic as well as activating properties on murine and human eosinophils respectively, and on the other hand a burst promoting activity. Its biochemical and biological features strongly suggest that this factor cannot be likened to any known human lymphokine.
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Journal articles
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https://hal-univ-tours.archives-ouvertes.fr/hal-02414892
Contributor : Valérie Gouilleux <>
Submitted on : Monday, December 16, 2019 - 6:34:15 PM
Last modification on : Thursday, March 26, 2020 - 2:14:07 AM

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  • HAL Id : hal-02414892, version 1
  • PUBMED : 3099991

Citation

J. Moreau, M. Bonneville, A. Godard, H Gascan, V Gruart, et al.. [Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1987, 304 (1), pp.5-10. ⟨hal-02414892⟩

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