[Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains]. - Archive ouverte HAL Access content directly
Journal Articles Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie Year : 1987

[Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].

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A. Godard
  • Function : Author
H Gascan
  • Function : Author
V Gruart
M Moore
  • Function : Author
J Soulillou
  • Function : Author

Abstract

Alloreactive T-cell clones obtained from cells infiltrating a human rejected kidney graft were shown to produce upon specific antigenic stimulation with interleukin 2, a factor triggering the proliferation of an interleukin 3 dependent murine cell line. The lymphokine responsible for this activity was a monomeric glycoprotein (MW = 41,000) exhibiting on one hand chemotactic as well as activating properties on murine and human eosinophils respectively, and on the other hand a burst promoting activity. Its biochemical and biological features strongly suggest that this factor cannot be likened to any known human lymphokine.
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Dates and versions

hal-02414892 , version 1 (16-12-2019)

Identifiers

  • HAL Id : hal-02414892 , version 1
  • PUBMED : 3099991

Cite

J. Moreau, M. Bonneville, A. Godard, H Gascan, V Gruart, et al.. [Characterization of a factor produced by human alloreactive T lymphocyte clones, active on the eosinophils and precursors of erythroid strains].. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1987, 304 (1), pp.5-10. ⟨hal-02414892⟩
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