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Eosinophil IgE receptor and CD23

Abstract : In the present review, eosinophil Fc epsilon RII was compared to CD23, a differentiation marker of B cells. Biochemical analysis revealed that molecules of similar molecular weight were immunoprecipitated from eosinophils and B cells by an anti-CD23 monoclonal antibody (mAb) or by BB10, and anti-eosinophil Fc epsilon RII. By flow cytometry, a correlation was found between the binding of anti-CD23 mAb and myeloma IgE. However, a low expression of different epitopes of CD23 was observed in various hypereosinophilic patients. Northern blot analysis of eosinophil RNA with the cDNA probe of CD23 revealed a weak message in only 3 of the 6 patients expressing membrane CD23. The inhibition by anti-CD23 mAbs of IgE-mediated cytotoxicity and IgE binding to eosinophils clearly indicated the participation of CD23 or a related molecule in IgE-dependent eosinophil functions. However, the differential effects of anti-CD23 mAbs on eosinophils and B cells suggest major differences in the characteristics of the molecule expressed by eosinophils and by B cells.
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https://hal-univ-tours.archives-ouvertes.fr/hal-02414254
Contributor : Valérie Gouilleux <>
Submitted on : Monday, December 16, 2019 - 3:23:33 PM
Last modification on : Friday, January 10, 2020 - 4:12:17 PM

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Monique Capron, Marie-José Truong, Delphine Aldebert, Valérie Gruart, Masaki Suemura, et al.. Eosinophil IgE receptor and CD23. Immunologic Research, Humana Press, 1992, 11 (3-4), pp.252-259. ⟨10.1007/bf02919131⟩. ⟨hal-02414254⟩

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