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Journal articles
Domino 6-endo-dig Cyclization/Halogenation Reactions: Three-Component Synthesis of 1,3-Disubstituted 4-Haloimidazo[1,2-a:4,5-c′]dipyridines
Abstract : A regiocontrolled 6-endo-dig cyclization of 3-ethynylimidazo[1,2-a]pyridine-2-carbonitriles promoted by Grignard reagent in the presence of iodine has been developed. We optimized the reaction conditions to allow the straightforward synthesis of 1,3-disubstituted 4-iodoimidazo[1,2-a:4,5-c]dipyridines. Finally, the reactivity of the 4-iodo position toward various metal-catalyzed coupling reactions (Suzuki-Miyaura, Sonogashira, etc.) or cyanation was successfully evaluated.
https://hal-univ-tours.archives-ouvertes.fr/hal-02389894
Contributor : Caroline Denevault-Sabourin <>
Submitted on : Monday, December 2, 2019 - 5:05:44 PM
Last modification on : Thursday, May 6, 2021 - 2:23:22 PM
Contributor : Caroline Denevault-Sabourin <>
Submitted on : Monday, December 2, 2019 - 5:05:44 PM
Last modification on : Thursday, May 6, 2021 - 2:23:22 PM