Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Jasmin Paris , Marcos Morgan , Joana Campos (1) , Gary Spencer , Alena Shmakova , Ivayla Ivanova , Christopher Mapperley , Hannah Lawson , David Wotherspoon , Catarina Sepulveda , Milica Vukovic (2) , Lewis Allen , Annika Sarapuu , Andrea Tavosanis , Amélie Guitart (3) , Arnaud Villacreces (3) , Christian Much , Junho Choe , Ali Azar , Louie van de Lagemaat , Douglas Vernimmen , Ali Nehme (4) , Frédéric Mazurier (5) , Tim C.P. Somervaille , Richard Gregory , Dónal O’carroll , Kamil Kranc (2)

1 LaSIGE [Lisboa]
2 Barts Cancer Institute - Centre for Haemato-Oncology [London, UK]
3 CIRID - Composantes innées de la réponse immunitaire et différenciation
4 UCBL - Université Claude Bernard Lyon 1
5 Transfert de Genes a Visee Therapeutique Dans les Cellules Souches

Domaines: Sciences du Vivant [q-bio]; Cancer

Jasmin Paris, Marcos Morgan, Joana Campos, Gary Spencer, Alena Shmakova, et al.. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩. ⟨hal-02389825⟩