Versatile electrostatically assembled polymeric siRNA nanovectors: Can they overcome the limits of siRNA tumor delivery? - Archive ouverte HAL Access content directly
Journal Articles International Journal of Pharmaceutics Year : 2019

Versatile electrostatically assembled polymeric siRNA nanovectors: Can they overcome the limits of siRNA tumor delivery?

(1) , (1) , (1) , (1) , (1)
1

Abstract

The application of small interfering RNA (siRNA) cancer therapeutics is limited by several extra- and intracellular barriers including the presence of ribonucleases that degrade siRNA, the premature clearance, the impermeability of the cell membrane, or the difficulty to escape endo-lysosomal degradation. Therefore, several delivery systems have emerged to overcome these limitations and to successfully deliver siRNA to the tumor site. This review is focused on polymer-based siRNA nanovectors which exploit the negative charge of siRNA, representing a major challenge for siRNA delivery, to their advantage by loading siRNA via electrostatic assembly. These nanovectors are easy to prepare and to adapt for an optimal gene silencing efficiency. The ability of electrostatically assembled polymeric siRNA nanovectors (EPSN) to improve the half-life of siRNA, to favor the specificity of the delivery and the accumulation in tumor and to enhance the cellular uptake and endosomal escape for an efficient siRNA delivery will be discussed. Finally, the influence of the versatility of the structure of these nanovectors on the protein down-regulation will be evaluated.
Fichier principal
Vignette du fichier
S0378517319304661.pdf (2.08 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-02182335 , version 1 (25-10-2021)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Sanaa Ben Djemaa, Emilie Munnier, Igor Chourpa, Emilie Allard-Vannier, Stephanie David. Versatile electrostatically assembled polymeric siRNA nanovectors: Can they overcome the limits of siRNA tumor delivery?. International Journal of Pharmaceutics, 2019, 567, pp.118432. ⟨10.1016/j.ijpharm.2019.06.023⟩. ⟨hal-02182335⟩

Collections

UNIV-TOURS
37 View
30 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More