Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

Francesca Bryden; Camille Martin; Stéphanie Letast; Eva Lles; Inmaculada Viéitez-Villemin; Anaïs Rousseau; Cyril Colas; Marie Brachet-Botineau; Emilie Allard-Vannier; Christel Larbouret; Marie-Claude Viaud-Massuard; Nicolas Joubert

Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

Francesca Bryden ¹ Camille Martin ¹ Stéphanie Letast ¹ Eva Lles ² Inmaculada Viéitez-Villemin ¹ Anaïs Rousseau ¹ Cyril Colas ³ Marie Brachet-Botineau ¹ Emilie Allard-Vannier ⁴ Christel Larbouret ² Marie-Claude Viaud-Massuard ¹ Nicolas Joubert ^{1, *}

* Corresponding author

1 GICC - Génétique, Immunothérapie, Chimie et Cancer

2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier

3 ICOA - Institut de Chimie Organique et Analytique

4 NMNS - Nanomédicaments et Nanosondes, EA 6295

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Cancer

Life Sciences [q-bio] / Biochemistry, Molecular Biology / Molecular biology

Life Sciences [q-bio] / Pharmaceutical sciences / Medication

Chemical Sciences / Analytical chemistry

Complete list of metadatas

https://hal-univ-tours.archives-ouvertes.fr/hal-01808620
Contributor : Martin Soucé <>
Submitted on : Tuesday, June 5, 2018 - 6:43:07 PM
Last modification on : Saturday, July 20, 2019 - 1:01:27 AM

Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

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Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

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