Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

Francesca Bryden 1 Camille Martin 1 Stéphanie Letast 1 Eva Lles 2 Inmaculada Viéitez-Villemin 1 Anaïs Rousseau 1 Cyril Colas 3 Marie Brachet-Botineau 1 Emilie Allard-Vannier 4 Christel Larbouret 2 Marie-Claude Viaud-Massuard 1 Nicolas Joubert 1, *
* Corresponding author
1 GICC UMR 7292 CNRS - Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017]
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 ICOA - Institut de Chimie Organique et Analytique
4 NMNS - Nanomédicaments et Nanosondes, EA 6295
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Submitted on : Tuesday, June 5, 2018 - 6:43:07 PM
Last modification on : Wednesday, December 4, 2019 - 2:38:03 PM

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Francesca Bryden, Camille Martin, Stéphanie Letast, Eva Lles, Inmaculada Viéitez-Villemin, et al.. Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (11), pp.1882 - 1889. ⟨10.1039/c7ob02780j⟩. ⟨hal-01808620⟩

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