Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

Francesca Bryden (1) , Camille Martin (1) , Stéphanie Letast (1) , Eva Lles (2) , Inmaculada Viéitez-Villemin (1) , Anaïs Mirault Rousseau (1) , Cyril Colas (3) , Marie Brachet-Botineau (1) , Emilie Allard-Vannier (4) , Christel Larbouret (2) , Marie-Claude Viaud-Massuard (1) , Nicolas Joubert (1)

1 GICC EA 7501 - Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...]
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 ICOA - Institut de Chimie Organique et Analytique
4 NMNS - Nanomédicaments et Nanosondes, EA 6295

Domains: Life Sciences [q-bio]; Cancer; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Molecular biology; Life Sciences [q-bio]; Pharmaceutical sciences; Medication; Chemical Sciences; Analytical chemistry

Francesca Bryden, Camille Martin, Stéphanie Letast, Eva Lles, Inmaculada Viéitez-Villemin, et al.. Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates. Organic & Biomolecular Chemistry, 2018, 16 (11), pp.1882 - 1889. ⟨10.1039/c7ob02780j⟩. ⟨hal-01808620⟩