Lipid-based submicron capsules as a strategy to include high concentrations of a hydrophobic lightening agent in a hydrogel

Hoang Truc Phuong Nguyen 1, 2 Martin Soucé 1 Xavier Perse 1 Francis Vial 3 Thomas Perrier, 4 Florent Yvergnaux 5 Igor Chourpa 1 Emilie Munnier 1, *
* Auteur correspondant
1 NMNS - Nanomédicaments et Nanosondes, EA 6295
2 Université Grenoble Alpes, DPM, UMR CNRS 5063, Grenoble
3 Spincontrol France, Tours, France
4 Carlina Technologies, Angers, France
5 Bioeurope Groupe Solabia
Abstract : OBJECTIVE: The present study aims at increasing the concentration of a hydrophobic lightening agent, Omegalight® , in a hydrophilic cosmetic product by means of encapsulation in lipid-based submicron capsules. The core of these capsules is entirely made of the commercial lightening agent. METHODS: Lipid-based encapsulation systems (LNC) were prepared by the PIT method. Their physicochemical properties were followed over 6 months by dynamic light scattering and zeta potential measurements, and in parallel the potential degradation of the active ingredient was monitored by HPLC. The stability of the capsules in a cosmetic gel was studied by spectrofluorimetry and rheology measurements. Sensory analysis was used to determine the influence of the presence of capsules in the gel on the consumer's experience. RESULTS: LNC encapsulating Omegalight® were prepared on a laboratory scale and then on a semi-pilot scale. Their hydrodynamic diameters are around 230 nm. The concentration of Omegalight® in the capsules reaches about 84% w/w, which corresponds to 42% of active ingredient. LNC can be dispersed without degradation at concentrations of up to 20% w/w in a hydrogel without modification of the physicochemical or sensory properties of the gel. CONCLUSION: Lipid-based capsules (LNC), an encapsulation system useful for the epidermal delivery of hydrophobic compounds, were adapted to the encapsulation of a commercial lightening agent. The encapsulation permits the dispersion in a stable manner of a very high concentration of a hydrophobic active molecule in a hydrogel while maintaining the physicochemical and sensory properties of the gel. This article is protected by copyright. All rights reserved.
Keywords : spectroscopy formulation/stability skin lightening Nanoencapsulation chemical analysis
Type de document :
Article dans une revue
International Journal of Cosmetic Science, Wiley, 2017, 39 (4), pp.450-456. 〈https://www.ncbi.nlm.nih.gov/pubmed/28295406〉. 〈10.1111/ics.12397〉
Liste complète des métadonnées
https://hal-univ-tours.archives-ouvertes.fr/hal-01515720
Contributeur : Martin Soucé <>
Soumis le : vendredi 28 avril 2017 - 09:40:51
Dernière modification le : mardi 23 octobre 2018 - 17:02:37

Identifiants

Collections

Citation

Hoang Truc Phuong Nguyen, Martin Soucé, Xavier Perse, Francis Vial, Thomas Perrier,, et al.. Lipid-based submicron capsules as a strategy to include high concentrations of a hydrophobic lightening agent in a hydrogel. International Journal of Cosmetic Science, Wiley, 2017, 39 (4), pp.450-456. 〈https://www.ncbi.nlm.nih.gov/pubmed/28295406〉. 〈10.1111/ics.12397〉. 〈hal-01515720〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

80

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD