Skip to Main content Skip to Navigation
Journal articles

Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

Matthieu Lavielle 1, 2 Denis Mulleman 1, 2 Philippe Goupille 1, 2 Clément Bahuaud 1 Hsueh Cheng 1, 3 Hervé Watier 3, 1 Gilles Thibault 1, 3
1 GICC UMR 7292 CNRS - Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017]
2 Service de rhumatologie
3 Laboratoire d'Immunologie
Abstract : Significant peripheral blood CD4+ T-cell depletion has been observed after a first cycle of rituximab, a monoclonal antibody directed against the CD20 antigen, which is currently used in rheumatoid arthritis. Of note, an absence of CD4+ T-cell decrease has been observed in non-responders. Herein, we describe CD4+ T-cell changes over repeated cycles of rituximab and their relationship with clinical outcomes.
Document type :
Journal articles
Complete list of metadatas

Cited literature [15 references]  Display  Hide  Download
https://hal-univ-tours.archives-ouvertes.fr/hal-01403387
Contributor : Denis Mulleman <>
Submitted on : Friday, November 25, 2016 - 7:40:55 PM
Last modification on : Wednesday, December 4, 2019 - 2:38:02 PM
Long-term archiving on: : Tuesday, March 21, 2017 - 4:15:19 AM

File

Vignette du document
Lavielle ART 2016.pdf
Publisher files allowed on an open archive

Identifiers

Collections

UNIV-TOURS | CNRS

Citation

Matthieu Lavielle, Denis Mulleman, Philippe Goupille, Clément Bahuaud, Hsueh Cheng, et al.. Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment. Arthritis Research and Therapy, BioMed Central, 2016, 58, pp.253. ⟨10.1186/s13075-016-1152-5⟩. ⟨hal-01403387⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

215

Files downloads

357