Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

Matthieu Lavielle 1, 2 Denis Mulleman 1, 2 Philippe Goupille 1, 2 Clément Bahuaud 1 Hsueh Cheng 1, 3 Hervé Watier 3, 1 Gilles Thibault 1, 3
1 GICC - Génétique, Immunothérapie, Chimie et Cancer
2 Service de rhumatologie
3 Laboratoire d'Immunologie
Abstract : Significant peripheral blood CD4+ T-cell depletion has been observed after a first cycle of rituximab, a monoclonal antibody directed against the CD20 antigen, which is currently used in rheumatoid arthritis. Of note, an absence of CD4+ T-cell decrease has been observed in non-responders. Herein, we describe CD4+ T-cell changes over repeated cycles of rituximab and their relationship with clinical outcomes.
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Matthieu Lavielle, Denis Mulleman, Philippe Goupille, Clément Bahuaud, Hsueh Cheng, et al.. Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment. Arthritis Research & Therapy, BioMed Central, 2016, 58, pp.253. ⟨10.1186/s13075-016-1152-5⟩. ⟨hal-01403387⟩

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