Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment - Archive ouverte HAL Access content directly
Journal Articles Arthritis Research and Therapy Year : 2016

Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

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Abstract

Significant peripheral blood CD4+ T-cell depletion has been observed after a first cycle of rituximab, a monoclonal antibody directed against the CD20 antigen, which is currently used in rheumatoid arthritis. Of note, an absence of CD4+ T-cell decrease has been observed in non-responders. Herein, we describe CD4+ T-cell changes over repeated cycles of rituximab and their relationship with clinical outcomes.
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hal-01403387 , version 1 (25-11-2016)

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Matthieu Lavielle, Denis Mulleman, Philippe Goupille, Clément Bahuaud, Hsueh Cheng, et al.. Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment. Arthritis Research and Therapy, 2016, 58, pp.253. ⟨10.1186/s13075-016-1152-5⟩. ⟨hal-01403387⟩

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