M. Johannessen, S. Moller, T. Hansen, U. Moens, and M. Van-ghelue, The multifunctional roles of the four-and-a-half-LIM only protein FHL2, Cellular and Molecular Life Sciences, vol.63, issue.3, pp.268-284, 2006.
DOI : 10.1007/s00018-005-5438-z

J. Muller, U. Isele, E. Metzger, A. Rempel, M. Moser et al., FHL2, a novel tissue-specific coactivator of the androgen receptor, The EMBO Journal, vol.19, issue.3, pp.359-369, 2000.
DOI : 10.1093/emboj/19.3.359

S. Kobayashi, H. Shibata, K. Yokota, N. Suda, A. Murai et al., FHL2, UBC9, and PIAS1 are Novel Estrogen Receptor ?????Interacting Proteins, Endocrine Research, vol.18, issue.4, pp.617-621, 2004.
DOI : 10.1081/ERC-200043789

L. Ding, Z. Wang, Y. J. Yang, X. Liu, A. Qiu et al., Human four-and-a-half LIM family FIG 7 Loss of FHL2 reduces hepatocyte proliferation after DEN exposure. (A) Liver RNA was extracted at the indicated times after DEN injection. The levels of IL-6, TNF, and FHL2 expression were determined by real-time RT-PCR. (B) Livers from DEN-exposed mice were isolated at the indicated times and homogenized . Phosphorylation of STAT3 was analyzed by Western blotting. (C) Immunohistochemistry on liver sections with Ki-67 antibody. (D) Reduced DNA synthesis in FHL2 / livers 24 h and 48 h after DEN exposure as determined by Ki-67 immunostaining, ***, P 0.0005. Apoptosis was detected by TUNEL. (E) Apoptosis was detected by TUNEL. (F) Quantification of TUNEL-positive cells in wt and FHL2 / livers 6 h, 15 h, 24 h, or 48 h after DEN exposure. *, P 0.05. FHL2 Participates in NF-B Signal Transduction, 2009.

D. Chen, W. Xu, E. Bales, C. Colmenares, M. Conacci-sorrell et al., SKI activates Wnt/beta-catenin signaling in human melanoma, Cancer Res, vol.63, pp.6626-6634, 2003.

T. Xia, L. Levy, F. Levillayer, B. Jia, G. Li et al., The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor ?? (TGF-??) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia, Journal of Biological Chemistry, vol.288, issue.3, pp.1785-1794, 2013.
DOI : 10.1074/jbc.M112.439760

A. Morlon and P. Sassone-corsi, The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1, Proc. Natl. Acad, 2003.
DOI : 10.1073/pnas.0735923100

B. Martin, R. Schneider, S. Janetzky, Z. Waibler, P. Pandur et al., The LIM-only protein FHL2 interacts with ??-catenin and promotes differentiation of mouse myoblasts, The Journal of Cell Biology, vol.113, issue.1, pp.113-122, 2002.
DOI : 10.1016/S0955-0674(96)80091-3

Y. Wei, C. Renard, C. Labalette, Y. Wu, L. Levy et al., Identification of the LIM Protein FHL2 as a Coactivator of ??-Catenin, Journal of Biological Chemistry, vol.278, issue.7, pp.5188-5194, 2003.
DOI : 10.1074/jbc.M207216200

C. Labalette, C. Renard, C. Neuveut, M. Buendia, and Y. Wei, Interaction and Functional Cooperation between the LIM Protein FHL2, CBP/p300, and ??-Catenin, Molecular and Cellular Biology, vol.24, issue.24, pp.10689-10702, 2004.
DOI : 10.1128/MCB.24.24.10689-10702.2004

J. Brun, O. Fromigue, F. Dieudonne, C. Marty, J. Chen et al., The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b, Bone, vol.51, issue.6, pp.6-12, 2012.
DOI : 10.1016/j.bone.2012.08.040

F. Mille, C. Thibert, J. Fombonne, N. Rama, C. Guix et al., The Patched dependence receptor triggers apoptosis through a DRAL???caspase-9 complex, Nature Cell Biology, vol.16, issue.2, pp.739-746, 2009.
DOI : 10.1073/pnas.0803645105

URL : https://hal.archives-ouvertes.fr/inserm-00405390

S. Bai, H. Kitaura, H. Zhao, J. Chen, J. Muller et al., FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner, Journal of Clinical Investigation, vol.115, issue.10, pp.2742-2751, 2005.
DOI : 10.1172/JCI24921

M. Hayden and S. Ghosh, NF-??B, the first quarter-century: remarkable progress and outstanding questions, Genes & Development, vol.26, issue.3, pp.203-234, 2012.
DOI : 10.1101/gad.183434.111

S. Smale, Hierarchies of NF-??B target-gene regulation, Nature Immunology, vol.12, issue.8, pp.689-694, 2011.
DOI : 10.1093/emboj/cdg370

C. Wong, G. Mak, M. Li, and S. Tsui, The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-??B pathway in muscle cells, Cytokine, vol.59, issue.2, pp.286-293, 2012.
DOI : 10.1016/j.cyto.2012.04.044

R. Stilo, A. Leonardi, L. Formisano, D. Jeso, B. Vito et al., TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-??B activation, FEBS Letters, vol.151, issue.1-3, pp.165-169, 2002.
DOI : 10.1016/S0014-5793(02)02869-7

B. Sun and K. M. , NF-??B signaling, liver disease and hepatoprotective agents, Oncogene, vol.13, issue.48, pp.6228-6244, 2008.
DOI : 10.1016/j.jhep.2007.08.008

A. Beg, W. Sha, R. Bronson, S. Ghosh, and D. Baltimore, Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-??B, Nature, vol.376, issue.6536, pp.167-170, 1995.
DOI : 10.1038/376167a0

F. Liu, Y. Xia, A. Parker, and I. Verma, IKK biology, Immunological Reviews, vol.246, issue.1, pp.239-253, 2012.
DOI : 10.1111/j.1600-065X.2012.01107.x

S. Maeda, H. Kamata, J. Luo, H. Leffert, and K. M. , IKK?? Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis, Cell, vol.121, issue.7, pp.977-990, 2005.
DOI : 10.1016/j.cell.2005.04.014

T. Luedde, N. Beraza, V. Kotsikoris, G. Van-loo, A. Nenci et al., Deletion of NEMO/IKK?? in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma, Cancer Cell, vol.11, issue.2, pp.119-132, 2007.
DOI : 10.1016/j.ccr.2006.12.016

E. Pikarsky, R. Porat, I. Stein, R. Abramovitch, S. Amit et al., NF-??B functions as a tumour promoter in inflammation-associated cancer, Nature, vol.2, issue.7007, pp.461-466, 2004.
DOI : 10.1006/scbi.2000.0360

Y. Nouet, J. Dahan, C. Labalette, F. Levillayer, B. Julien et al., The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis, Journal of Hepatology, vol.57, issue.5, pp.1029-1036, 2012.
DOI : 10.1016/j.jhep.2012.06.035

P. Chu, W. Bardwell, Y. Gu, R. J. Jr, and C. J. , FHL2 (SLIM3) Is Not Essential for Cardiac Development and Function, Molecular and Cellular Biology, vol.20, issue.20, pp.7460-7462, 2000.
DOI : 10.1128/MCB.20.20.7460-7462.2000

A. Nicou, V. Serriere, S. Prigent, S. Boucherie, L. Combettes et al., Hypothalamic vasopressin release and hepatocyte Ca2 signaling during liver regeneration: an interplay stimulating liver growth and bile flow, FASEB J, vol.17, pp.1901-1903, 2003.

D. Cougot, E. Allemand, L. Riviere, S. Benhenda, K. Duroure et al., Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription, Science Signaling, vol.5, issue.205, p.1, 2012.
DOI : 10.1126/scisignal.2001906

L. Guillot, V. Balloy, F. Mccormack, D. Golenbock, M. Chignard et al., Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4, The Journal of Immunology, vol.168, issue.12, pp.5989-5992, 2002.
DOI : 10.4049/jimmunol.168.12.5989

A. Leroux, G. Ferrere, V. Godie, F. Cailleux, M. Renoud et al., Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis, Journal of Hepatology, vol.57, issue.1, pp.141-149, 2012.
DOI : 10.1016/j.jhep.2012.02.028

URL : https://hal.archives-ouvertes.fr/hal-01001408

R. Taub, Liver regeneration: from myth to mechanism, Nature Reviews Molecular Cell Biology, vol.135, issue.10, pp.836-847, 2004.
DOI : 10.1073/pnas.220430497

N. Fausto, A. Laird, and E. Webber, Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration, FASEB J, vol.9, pp.1527-1536, 1995.

K. Teramoto, J. Bowers, U. Khettry, J. Palombo, and M. Clouse, A RAT FATTY LIVER TRANSPLANT MODEL, Transplantation, vol.55, issue.4, pp.737-741, 1993.
DOI : 10.1097/00007890-199304000-00010

M. Weltman, G. Farrell, and C. Liddle, Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation, Gastroenterology, vol.111, issue.6, pp.1645-1653, 1996.
DOI : 10.1016/S0016-5085(96)70028-8

R. Cornell, B. Liljequist, and K. Bartizal, Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice, Hepatology, vol.88, issue.6, pp.916-922, 1990.
DOI : 10.1002/hep.1840110603

G. He and K. M. , NF-??B and STAT3 ??? key players in liver inflammation and cancer, Cell Research, vol.65, issue.1, pp.159-168, 2011.
DOI : 10.1016/j.cell.2009.12.052

W. Naugler, T. Sakurai, S. Kim, S. Maeda, K. Kim et al., Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production, Science, vol.317, issue.5834, pp.121-124, 2007.
DOI : 10.1126/science.1140485

G. He, G. Yu, V. Temkin, H. Ogata, C. Kuntzen et al., Hepatocyte IKK??/NF-??B Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation, Cancer Cell, vol.17, issue.3, pp.286-297, 2010.
DOI : 10.1016/j.ccr.2009.12.048

L. Deng, C. Wang, E. Spencer, L. Yang, A. Braun et al., Activation of the I??B Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain, Cell, vol.103, issue.2, pp.351-361, 2000.
DOI : 10.1016/S0092-8674(00)00126-4

Z. Chen, Ubiquitin signalling in the NF-??B pathway, Nature Cell Biology, vol.308, issue.8, pp.758-765, 2005.
DOI : 10.1016/j.febslet.2004.08.071

M. Hubbi, D. Gilkes, J. Baek, and G. Semenza, Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1, Journal of Biological Chemistry, vol.287, issue.9, pp.6139-6149, 2012.
DOI : 10.1074/jbc.M111.278630

S. Bai, J. Zha, H. Zhao, F. Ross, and S. Teitelbaum, Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts, Journal of Biological Chemistry, vol.283, issue.45, pp.30861-30867, 2008.
DOI : 10.1074/jbc.M802525200

Z. Qian, L. Mao, A. Fernald, H. Yu, R. Luo et al., Enhanced expression of FHL2 leads to abnormal myelopoiesis in vivo, Leukemia, vol.24, issue.9, pp.1650-1657, 2009.
DOI : 10.1016/S0092-8674(02)00738-9

C. Labalette, Y. Nouet, F. Levillayer, S. Colnot, J. Chen et al., Deficiency of the LIM-Only Protein FHL2 Reduces Intestinal Tumorigenesis in Apc Mutant Mice, PLoS ONE, vol.5, issue.4, 2010.
DOI : 10.1371/journal.pone.0010371.g005