J. Taubenberger and D. Morens, The Pathology of Influenza Virus Infections, Annual Review of Pathology: Mechanisms of Disease, vol.3, issue.1, pp.499-522, 2008.
DOI : 10.1146/annurev.pathmechdis.3.121806.154316

T. Thanh, H. Van-doorn, and M. De-jong, Human H5N1 influenza: Current insight into pathogenesis, The International Journal of Biochemistry & Cell Biology, vol.40, issue.12, pp.2671-2675, 2008.
DOI : 10.1016/j.biocel.2008.05.019

L. Gruta, N. Kedzierska, K. Stambas, J. Doherty, and P. , A question of self-preservation: immunopathology in influenza virus infection, Immunology and Cell Biology, vol.194, issue.2, pp.85-92, 2007.
DOI : 10.1038/sj.icb.7100026

F. Hayden, Developing New Antiviral Agents for Influenza Treatment: What Does the Future Hold?, Clinical Infectious Diseases, vol.48, issue.S1, pp.3-13, 2009.
DOI : 10.1086/591851

O. Takeuchi and S. Akira, Pattern Recognition Receptors and Inflammation, Cell, vol.140, issue.6, pp.805-825, 2010.
DOI : 10.1016/j.cell.2010.01.022

URL : http://doi.org/10.1016/j.cell.2010.01.022

H. Chi and R. Flavell, Innate recognition of non-self nucleic acids, Genome Biology, vol.9, issue.3, p.211, 2008.
DOI : 10.1186/gb-2008-9-3-211

J. Pothlichet, I. Meunier, and B. Davis, Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells, PLoS Pathogens, vol.85, issue.4, p.1003256, 2013.
DOI : 10.1371/journal.ppat.1003256.s012

URL : https://hal.archives-ouvertes.fr/pasteur-01132212

J. Pothlichet, M. Chignard, and M. Si-tahar, Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway, The Journal of Immunology, vol.180, issue.4, pp.2034-2042, 2008.
DOI : 10.4049/jimmunol.180.4.2034

URL : https://hal.archives-ouvertes.fr/pasteur-00206322

L. Goffic, R. Pothlichet, J. Vitour, and D. , Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells, The Journal of Immunology, vol.178, issue.6, pp.3368-72, 2007.
DOI : 10.4049/jimmunol.178.6.3368

L. Guillot, L. Goffic, R. Bloch, and S. , Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus, Journal of Biological Chemistry, vol.280, issue.7, pp.5571-80, 2005.
DOI : 10.1074/jbc.M410592200

L. Goffic, R. Balloy, V. Lagranderie, and M. , Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus???Induced Acute Pneumonia, PLoS Pathogens, vol.9, issue.6, p.53, 2006.
DOI : 1074-7613(1998)009[0143:TDOTMG]2.0.CO;2

Y. Wang, H. Zhang, and Y. Sun, Rig-I???/??? mice develop colitis associated with downregulation of G??i2, Cell Research, vol.158, issue.10, pp.858-68, 2007.
DOI : 10.1046/j.1365-3083.2000.00759.x

H. Kato, S. Sato, and M. Yoneyama, Cell Type-Specific Involvement of RIG-I in Antiviral Response, Immunity, vol.23, issue.1, pp.19-28, 2005.
DOI : 10.1016/j.immuni.2005.04.010

D. Vitour and E. Meurs, Regulation of Interferon Production by RIG-I and LGP2: A Lesson in Self-Control, Science's STKE, vol.2007, issue.384, p.20, 2007.
DOI : 10.1126/stke.3842007pe20

K. Childs, R. Randall, and S. Goodbourn, LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA, PLoS ONE, vol.288, issue.5, p.64202, 2013.
DOI : 10.1371/journal.pone.0064202.s001

S. Rothenfusser, N. Goutagny, and G. Diperna, The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I, The Journal of Immunology, vol.175, issue.8, pp.5260-5268, 2005.
DOI : 10.4049/jimmunol.175.8.5260

T. Satoh, H. Kato, and Y. Kumagai, LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses, Proceedings of the National Academy of Sciences, vol.107, issue.4, pp.1512-1519, 2010.
DOI : 10.1073/pnas.0912986107

T. Venkataraman, M. Valdes, and R. Elsby, Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses, The Journal of Immunology, vol.178, issue.10, pp.6444-55, 2007.
DOI : 10.4049/jimmunol.178.10.6444

D. Chopy, J. Pothlichet, and M. Lafage, Ambivalent Role of the Innate Immune Response in Rabies Virus Pathogenesis, Journal of Virology, vol.85, issue.13, pp.6657-68, 2011.
DOI : 10.1128/JVI.00302-11

URL : https://hal.archives-ouvertes.fr/pasteur-00591084

M. Suthar, H. Ramos, and M. Brassil, The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness, Immunity, vol.37, issue.2, pp.235-283, 2012.
DOI : 10.1016/j.immuni.2012.07.004

M. Malur, M. Gale, . Jr, and R. Krug, LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3, Journal of Virology, vol.86, issue.19, pp.10733-10741, 2012.
DOI : 10.1128/JVI.00510-12

J. Pothlichet, A. Burtey, and A. Kubarenko, Study of Human RIG-I Polymorphisms Identifies Two Variants with an Opposite Impact on the Antiviral Immune Response, PLoS ONE, vol.4, issue.10, p.7582, 2009.
DOI : 10.1371/journal.pone.0007582.s004

URL : https://hal.archives-ouvertes.fr/pasteur-00455204

K. Wikenheiser, D. Vorbroker, and W. Rice, Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice., Proceedings of the National Academy of Sciences, vol.90, issue.23, pp.11029-11062, 1993.
DOI : 10.1073/pnas.90.23.11029

L. Guillot, S. Medjane, and K. Le-barillec, Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways, Journal of Biological Chemistry, vol.279, issue.4, pp.2712-2720, 2004.
DOI : 10.1074/jbc.M305790200

T. Saito, R. Hirai, and Y. Loo, Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2, Proceedings of the National Academy of Sciences, vol.104, issue.2, pp.582-589, 2007.
DOI : 10.1073/pnas.0606699104

A. Beignon, K. Mollier, and C. Liard, Lentiviral Vector-Based Prime/Boost Vaccination against AIDS: Pilot Study Shows Protection against Simian Immunodeficiency Virus SIVmac251 Challenge in Macaques, Journal of Virology, vol.83, issue.21, pp.10963-74, 2009.
DOI : 10.1128/JVI.01284-09

URL : https://hal.archives-ouvertes.fr/pasteur-00457819

C. Giannini, S. Morosan, and J. Tralhao, A highly efficient, stable, and rapid approach for ex vivo human liver gene therapy via a FLAP lentiviral vector, Hepatology, vol.8, issue.1, pp.114-136, 2003.
DOI : 10.1053/jhep.2003.50265

M. Ikawa, N. Tanaka, W. Kao, and I. Verma, Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy, Molecular Therapy, vol.8, issue.4, pp.666-73, 2003.
DOI : 10.1016/S1525-0016(03)00240-5

M. Santoro, A. Rossi, and C. Amici, NEW EMBO MEMBER'S REVIEW: NF-kappaB and virus infection: who controls whom, The EMBO Journal, vol.22, issue.11, pp.2552-60, 2003.
DOI : 10.1093/emboj/cdg267

M. Song, Y. Cho, and S. Park, Early Regulation of Viral Infection Reduces Inflammation and Rescues Mx-Positive Mice from Lethal Avian Influenza Infection, The American Journal of Pathology, vol.182, issue.4, pp.1308-1329, 2013.
DOI : 10.1016/j.ajpath.2012.12.022

W. Kok, L. Denney, and K. Benam, Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection, Journal of Leukocyte Biology, vol.91, issue.3, pp.357-68, 2012.
DOI : 10.1189/jlb.0411184

J. Grommes and O. Soehnlein, Contribution of neutrophils to acute lung injury, Mol Med, vol.17, pp.293-307, 2011.

K. Lin, S. Sweeney, B. Kang, E. Ramsburg, and M. Gunn, CCR2-Antagonist Prophylaxis Reduces Pulmonary Immune Pathology and Markedly Improves Survival during Influenza Infection, The Journal of Immunology, vol.186, issue.1, pp.508-523, 2011.
DOI : 10.4049/jimmunol.1001002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723340

S. Belisle, J. Tisoncik, and M. Korth, Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-??) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-?? Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection, Journal of Virology, vol.84, issue.24, pp.12576-88, 2010.
DOI : 10.1128/JVI.01310-10

T. Hussell, A. Pennycook, and P. Openshaw, Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology, European Journal of Immunology, vol.77, issue.9
DOI : 10.1002/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L

R. Peper and H. Van-campen, Tumor necrosis factor as a mediator of inflammation in influenza A viral pneumonia, Microbial Pathogenesis, vol.19, issue.3, pp.175-83, 1995.
DOI : 10.1006/mpat.1995.0056

J. Larrubia, S. Benito-martinez, M. Calvino, E. Sanz-de-villalobos, and T. Parra-cid, Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection, World Journal of Gastroenterology, vol.14, issue.47, pp.7149-59, 2008.
DOI : 10.3748/wjg.14.7149

A. Maghazachi, Role of Chemokines in the Biology of Natural Killer Cells, Curr Top Microbiol Immunol, vol.341, pp.37-58, 2010.
DOI : 10.1007/82_2010_20

E. Stanley, K. Berg, and D. Einstein, Biology and action of colony-stimulating factor-1, Molecular Reproduction and Development, vol.345, issue.1, pp.4-10, 1997.
DOI : 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V

G. Davatelis, P. Tekamp-olson, and S. Wolpe, Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties [published erratum appears in J Exp Med 1989 Dec 1;170(6):2189], Journal of Experimental Medicine, vol.167, issue.6, pp.1939-1983, 1988.
DOI : 10.1084/jem.167.6.1939

S. Wolpe, G. Davatelis, and B. Sherry, Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties, Journal of Experimental Medicine, vol.167, issue.2, pp.570-81, 1988.
DOI : 10.1084/jem.167.2.570

L. Xu, M. Warren, W. Rose, W. Gong, and J. Wang, Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro, J Leukoc Biol, vol.60, pp.365-71, 1996.

M. Sarafi, E. Garcia-zepeda, J. Maclean, I. Charo, and A. Luster, Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1, The Journal of Experimental Medicine, vol.153, issue.1
DOI : 10.1084/jem.183.2.681

G. Jia, J. Gonzalo, and C. Lloyd, Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation, Journal of Experimental Medicine, vol.184, issue.5, pp.1939-51, 1996.
DOI : 10.1084/jem.184.5.1939

O. Ishibashi, M. Ali, and S. Luo, Short RNA duplexes elicit RIG-Imediated apoptosis in a cell type-and length-dependent manner, Sci Signal, vol.4, p.74, 2011.

S. Sakai, H. Kawamata, and N. Mantani, Therapeutic Effect of Anti-Macrophage Inflammatory Protein 2 Antibody on Influenza Virus-Induced Pneumonia in Mice, Journal of Virology, vol.74, issue.5, pp.2472-2478, 2000.
DOI : 10.1128/JVI.74.5.2472-2476.2000

U. Walter and P. Santamaria, CD8+ T cells in autoimmunity, Current Opinion in Immunology, vol.17, issue.6, pp.624-655, 2005.
DOI : 10.1016/j.coi.2005.09.014