H. J. Muller, The remaking of chromosomes, Collecting Net, vol.13, pp.181-195, 1938.

B. Mcclintock, The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion, Proceedings of the National Academy of Sciences, vol.28, issue.11
DOI : 10.1073/pnas.28.11.458

M. P. Longhese, DNA damage response at functional and dysfunctional telomeres, Genes & Development, vol.22, issue.2, pp.125-140, 2008.
DOI : 10.1101/gad.1626908

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731633

T. De-lange, How Telomeres Solve the End-Protection Problem, Science, vol.326, issue.5955, pp.948-952, 2009.
DOI : 10.1126/science.1170633

V. E. Gilson and . Géli, How telomeres are replicated, Nature Reviews Molecular Cell Biology, vol.66, issue.10, pp.825-838, 2007.
DOI : 10.1038/nrm2259

S. Marcand, E. Gilson, and D. Shore, A Protein-Counting Mechanism for Telomere Length Regulation in Yeast, Science, vol.275, issue.5302, pp.986-990, 1997.
DOI : 10.1126/science.275.5302.986

B. Pardo and S. Marcand, Rap1 prevents telomere fusions by nonhomologous end joining, The EMBO Journal, vol.12, issue.17
DOI : 10.1038/sj.emboj.7600778

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201357

S. Marcand, B. Pardo, A. Gratias, S. Cahun, and I. Callebaut, Multiple pathways inhibit NHEJ at telomeres, Genes & Development, vol.22, issue.9, pp.1153-1158, 2008.
DOI : 10.1101/gad.455108

URL : https://hal.archives-ouvertes.fr/hal-00261858

W. Palm and T. De-lange, How Shelterin Protects Mammalian Telomeres, Annual Review of Genetics, vol.42, issue.1, pp.301-334, 2008.
DOI : 10.1146/annurev.genet.41.110306.130350

S. Gravel, M. Larrivée, P. Labrecque, and R. J. Wellinger, Yeast Ku as a Regulator of Chromosomal DNA End Structure, Science, vol.280, issue.5364, pp.741-744, 1998.
DOI : 10.1126/science.280.5364.741

B. Garvik, M. Carson, and L. Hartwell, Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint., Molecular and Cellular Biology, vol.15, issue.11, pp.6128-6138, 1995.
DOI : 10.1128/MCB.15.11.6128

N. Grandin, S. I. Reed, and M. Charbonneau, Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13., Genes & Development, vol.11, issue.4, pp.512-527, 1997.
DOI : 10.1101/gad.11.4.512

N. Grandin, C. Damon, and M. Charbonneau, Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13, The EMBO Journal, vol.20, issue.5, pp.1173-1183, 2001.
DOI : 10.1093/emboj/20.5.1173

URL : https://hal.archives-ouvertes.fr/hal-00077633

D. Shore and A. Bianchi, Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase, The EMBO Journal, vol.8, issue.16, pp.2309-2322, 2009.
DOI : 10.1038/nsmb.1471

J. S. Mcgee, J. A. Phillips, A. Chan, M. Sabourin, K. Paeschke et al., Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair, Nature Structural & Molecular Biology, vol.63, issue.12, pp.17-1438, 2010.
DOI : 10.1038/nsmb.1947

A. Bianchi and A. D. Shore, Increased association of telomerase with short telomeres in yeast, Genes & Development, vol.21, issue.14, pp.1726-1730, 2007.
DOI : 10.1101/gad.438907

M. Chang, M. Arneric, and J. Lingner, Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1

R. E. Hector, R. L. Shtofman, A. Ray, B. R. Chen, T. Nyun et al., Tel1p Preferentially Associates with Short Telomeres to Stimulate Their Elongation, Molecular Cell, vol.27, issue.5, pp.851-858, 2007.
DOI : 10.1016/j.molcel.2007.08.007

M. Sabourin, C. T. Tuzon, and V. A. Zakian, Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae, Molecular Cell, vol.27, issue.4, pp.550-561, 2007.
DOI : 10.1016/j.molcel.2007.07.016

V. Viscardi, D. Bonetti, H. Cartagena-lirola, G. Lucchini, and M. P. Longhese, MRX-dependent DNA Damage Response to Short Telomeres, Molecular Biology of the Cell, vol.18, issue.8, pp.3047-3058, 2007.
DOI : 10.1091/mbc.E07-03-0285

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949382

S. K. Binz, A. M. Sheehan, and M. S. Wold, Replication Protein A phosphorylation and the cellular response to DNA damage, DNA Repair, vol.3, issue.8-9, pp.1015-1024, 2004.
DOI : 10.1016/j.dnarep.2004.03.028

K. Sakaguchi, T. Ishibashi, Y. Uchiyama, and K. Iwabata, The multi-replication protein???A (RPA) system - a new perspective, FEBS Journal, vol.70, issue.Pt 2, pp.943-963, 2009.
DOI : 10.1111/j.1742-4658.2008.06841.x

S. Broderick, K. Rehmet, C. Concannon, and H. P. Nasheuer, Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability, Subcell. Biochem, pp.50-143, 2010.
DOI : 10.1007/978-90-481-3471-7_8

R. L. Flynn and L. Zou, Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians, Critical Reviews in Biochemistry and Molecular Biology, vol.100, issue.5, pp.45-266, 2010.
DOI : 10.1128/MCB.14.1.310

H. S. Kim and S. J. Brill, Rfc4 Interacts with Rpa1 and Is Required for Both DNA Replication and DNA Damage Checkpoints in Saccharomyces cerevisiae, Molecular and Cellular Biology, vol.21, issue.11, pp.3725-3737, 2001.
DOI : 10.1128/MCB.21.11.3725-3737.2001

L. Zou and S. J. Elledge, Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes, Science, vol.300, issue.5625, pp.1542-1548, 2003.
DOI : 10.1126/science.1083430

L. Karlseder and . Zou, TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA, Nature, vol.471, pp.532-536, 2011.

R. L. Flynn, S. Chang, and L. Zou, RPA and POT1, Cell Cycle, vol.13, issue.4, pp.652-657, 2012.
DOI : 10.1128/MCB.24.5.2091-102.2004

S. E. Artandi and R. A. Depinho, Telomeres and telomerase in cancer, Carcinogenesis, vol.31, issue.1, pp.9-18, 2010.
DOI : 10.1093/carcin/bgp268

A. S. Ivessa, J. Q. Zhou, V. P. Schulz, E. K. Monson, and V. A. Zakian, Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA, Genes & Development, vol.16, issue.11, pp.1383-1396, 2002.
DOI : 10.1101/gad.982902

S. Makovets, I. Herskowitz, and E. H. Blackburn, Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions, Molecular and Cellular Biology, vol.24, issue.9, pp.4019-4031, 2004.
DOI : 10.1128/MCB.24.9.4019-4031.2004

N. Fouché, S. Özgür, D. Roy, and J. D. Griffith, Replication fork regression in repetitive DNAs, Nucleic Acids Research, vol.34, issue.20
DOI : 10.1093/nar/gkl757

N. Grandin and M. Charbonneau, Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA, Nucleic Acids Research, vol.35, issue.3, pp.822-838, 2007.
DOI : 10.1093/nar/gkl1081

N. Grandin, C. Damon, and M. Charbonneau, Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination, The EMBO Journal, vol.20, issue.21, pp.6127-6139, 2001.
DOI : 10.1093/emboj/20.21.6127

URL : https://hal.archives-ouvertes.fr/hal-00077620

K. Umezu, N. Sugawara, C. Chen, J. E. Haber, and R. D. Kolodner, Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism, Genetics, vol.148, pp.989-1005, 1998.

V. Lundblad and E. H. Blackburn, An alternative pathway for yeast telomere maintenance rescues est1??? senescence, Cell, vol.73, issue.2, pp.347-360, 1993.
DOI : 10.1016/0092-8674(93)90234-H

T. A. Weinert, G. L. Kiser, and L. H. Hartwell, Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair., Genes & Development, vol.8, issue.6, pp.652-665, 1994.
DOI : 10.1101/gad.8.6.652

J. S. Searle, K. L. Schollaert, B. J. Wilkins, and Y. Sanchez, The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression, Nature Cell Biology, vol.14, issue.2
DOI : 10.1016/S1369-5274(00)00142-9

L. H. Hartwell and T. A. Weinert, Checkpoints: controls that ensure the order of cell cycle events, Science, vol.246, issue.4930, pp.629-634, 1989.
DOI : 10.1126/science.2683079

T. A. Weinert and L. H. Hartwell, Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint, Genetics, vol.134, pp.63-80, 1993.

D. Lydall and T. Weinert, Use of cdc13-1-induced DNA damage to study effects of checkpoint genes on DNA damage processing, Methods Enzymol, vol.283, pp.410-424, 1997.
DOI : 10.1016/S0076-6879(97)83034-0

M. J. Carson and L. Hartwell, CDC17: An essential gene that prevents telomere elongation in yeast, Cell, vol.42, issue.1, pp.249-257, 1985.
DOI : 10.1016/S0092-8674(85)80120-3

A. Valsasnini, S. Comedini, G. Piatti, and . Lucchini, The yeast DNA polymerase-primase complex: genes and proteins, Biochim. Biophys. Acta, vol.951, pp.268-273, 1988.

L. Maringele and D. , EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70? mutants

M. K. Zubko, S. Guillard, and D. , Exo1 and Rad24 Differentially Regulate Generation of ssDNA at Telomeres of Saccharomyces cerevisiae cdc13-1 Mutants, Genetics, vol.168, issue.1, pp.103-115, 2004.
DOI : 10.1534/genetics.104.027904

J. M. Dewar and D. , Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping, The EMBO Journal, vol.11, issue.23, pp.4020-4034, 2010.
DOI : 10.1016/S0076-6879(05)09016-6

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020640

. Durocher, A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator, Cell, vol.12, pp.1155-1168, 2006.

S. Le, J. K. Moore, J. E. Haber, and C. W. Greider, RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase, Genetics, vol.15, pp.143-152, 1999.

Q. Chen, A. Iijpma, and C. W. Greider, Two Survivor Pathways That Allow Growth in the Absence of Telomerase Are Generated by Distinct Telomere Recombination Events, Molecular and Cellular Biology, vol.21, issue.5
DOI : 10.1128/MCB.21.5.1819-1827.2001

H. Takata, Y. Kanoh, N. Gunge, K. Shirahige, and A. Matsuura, Reciprocal Association of the Budding Yeast ATM-Related Proteins Tel1 and Mec1 with Telomeres In Vivo, Molecular Cell, vol.14, issue.4, pp.515-522, 2004.
DOI : 10.1016/S1097-2765(04)00262-X

D. Bosoy, Y. Peng, I. Saira-mian, and N. F. Lue, Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in Vivo, Journal of Biological Chemistry, vol.278, issue.6, pp.278-3882, 2003.
DOI : 10.1074/jbc.M210645200

N. Grandin and M. Charbonneau, The Rad51 Pathway of Telomerase-Independent Maintenance of Telomeres Can Amplify TG1-3 Sequences in yku and cdc13 Mutants of Saccharomyces cerevisiae, Molecular and Cellular Biology, vol.23, issue.11, pp.3721-3734, 2003.
DOI : 10.1128/MCB.23.11.3721-3734.2003

V. Lundblad and J. W. Szostak, A mutant with a defect in telomere elongation leads to senescence in yeast, Cell, vol.57, issue.4, pp.633-643, 1989.
DOI : 10.1016/0092-8674(89)90132-3

J. Smith, R. Zou, and . Rothstein, Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance, Biochimie, vol.82, issue.1, pp.71-78, 2000.
DOI : 10.1016/S0300-9084(00)00183-8

. Géli, RPA regulates telomerase action by providing Est1p access to chromosome ends

. Géli, RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts

M. J. Mceachern and J. E. Haber, Break-Induced Replication and Recombinational Telomere Elongation in Yeast, Annual Review of Biochemistry, vol.75, issue.1, pp.111-135, 2006.
DOI : 10.1146/annurev.biochem.74.082803.133234

L. Shirihai, R. A. Chin, and . Depinho, Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer, Cell, vol.148, pp.651-663, 2012.

J. B. Vannier, V. Pavicic-kaltenbrunner, M. I. Petalcorin, H. Ding, and S. J. Boulton, RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity, Cell, vol.149, issue.4, pp.795-806, 2012.
DOI : 10.1016/j.cell.2012.03.030

R. Chin, R. D. Kucherlapati, W. Kolodner, and . Edelmann, Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice, Nat. Genet, pp.37-750, 2005.

. Deshaies, Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast

K. Myung, C. Chen, and R. D. Kolodner, Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae, Nature, vol.411, issue.6841, pp.1073-1076, 2001.
DOI : 10.1038/35082608

A. Bochkarev, R. A. Pfuetzner, A. M. Edwards, and L. Frappier, Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA, Nature, vol.385, issue.6612, pp.176-181, 1997.
DOI : 10.1038/385176a0

M. D. Rose, P. Novick, J. H. Thomas, D. Botstein, and G. R. Fink, A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector, Gene, vol.60, issue.2-3, pp.237-243, 1987.
DOI : 10.1016/0378-1119(87)90232-0

R. D. Gietz and A. Sugino, New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites, Gene, vol.74, issue.2, pp.527-534, 1988.
DOI : 10.1016/0378-1119(88)90185-0

Z. Sun, D. S. Fay, F. Marini, M. Foiani, and D. F. Stern, Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways., Genes & Development, vol.10, issue.4
DOI : 10.1101/gad.10.4.395