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α-synuclein filaments bind the transcriptional regulator HMGB-1

Abstract : Abnormal accumulation of alpha-synuclein filaments in Lewy bodies is a neuropathological hallmark of Parkinson's disease and sequestration of cellular protein into these protein aggregates may contribute to the degenerative process. We identified the transcriptional co-factor high mobility group protein 1 (HMGB-1) as a ligand for alpha-synuclein filaments by a filament spin-down technique, mass spectrometric peptide mapping and immunoblotting. HMGB-1 binds preferentially to aggregated alpha-synuclein and is present in alpha-synuclein filament-containing Lewy bodies isolated from brain tissue affected with dementia with Lewy bodies or Parkinson's disease. Our results demonstrate that alpha-synuclein filaments hold the potential for disturbing the cellular gene expression as they can sequester a component involved in cellular transcription regulation.
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https://hal.archives-ouvertes.fr/hal-00088420
Contributor : Isabelle Frapart <>
Submitted on : Wednesday, June 30, 2021 - 5:20:29 PM
Last modification on : Wednesday, July 7, 2021 - 8:58:47 AM

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Distributed under a Creative Commons Attribution 4.0 International License

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  • HAL Id : hal-00088420, version 1
  • PUBMED : 15597044

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E.K. Lindersson, P. Højrup, W.P. Gai, D. Locker, D. Martin, et al.. α-synuclein filaments bind the transcriptional regulator HMGB-1. NeuroReport, Lippincott, Williams & Wilkins, 2004, 15, pp.2735-2739. ⟨hal-00088420⟩

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