Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins

Abstract : BCL-2 proteins correspond to a structurally, functionally, and phylogenetically heterogeneous group of regulators that play crucial roles in the life and death of animal cells. Some of these regulators also represent therapeutic targets in human diseases including cancer. In the omics era, there is great need for easy data retrieval and fast analysis of the molecular players involved in cell death. In this chapter, we present generic and specific computational resources (such as the reference database BCL2DB) as well as bioinformatics tools that can be used to investigate BCL-2 homologs and BH3-only proteins.
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Abdel Aouacheria, Vincent Navratil, Christophe Combet. Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins. Gavathiotis E. BCL-2 Family Proteins. Methods in Molecular Biology, 1877, ⟨Springer Nature⟩, pp.23-43, 2019, Methods in Molecular Biology, 978-1-4939-8860-0. ⟨10.1007/978-1-4939-8861-7_2⟩. ⟨hal-02347884⟩

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